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<p>Oxidase-mimicking nanozymes are more desirable for applications than peroxidase-mimicking ones owing to H<sub>2</sub>O<sub>2</sub> can be omitted. In this work, a facile strategy was reported to prepare a series of Co-based bimetallic oxide nanosheets (Co–M–O NSs, M = Fe, Ni, Mn) derived from different isomorphism precursors. Herein, a comprehensive and systematic research of oxidase-like enzymes based on distinctions of elemental surface content and surface state has been undertaken. The porous Co–Mn–O NSs made of Mn-doping Co<sub>3</sub>O<sub>4</sub> can lead to decrease the size of Co<sub>3</sub>O<sub>4</sub> nanoparticle from 20–50 to 20–30&#xa0;nm, and increase in oxygen vacancy from 20.7% to 21.8%. The Co–Mn–O NSs via the Mn-doping could highly enhanced the performance and efficiency of the oxidase-mimicking, which is 7.5 times than that of Co<sub>3</sub>O<sub>4</sub> and other elements (Ni, Fe) doping Co<sub>3</sub>O<sub>4</sub>. Considering the features of Co–Mn–O NSs, a sensitive and selective colorimetric assay for the detection of L-cysteine (L-cys) was established. The system showed a linear absorbance response to L-cys concentrations ranging from 0.8 to 70&#xa0;μM, with a detection limit of 0.79&#xa0;μM. This facile and effective fabrication strategy of Co–Mn–O NSs has discovered a highly efficient oxidase-mimicking nanozyme useful in environmental protection, biotechnology, and clinical diagnosis.</p>

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Facile synthesis of porous M-doped Co3O4 as high-performance oxidase-mimicking nanozymes for colorimetric assay of L-cysteine

  • 期刊论文

  • 发表日期：

    2025年1月16日

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  • Chao Chen,
  • Lei Xia,
  • Yuxi Luo,
  • Siyang Fan,
  • Yuxin Wang

摘要

Oxidase-mimicking nanozymes are more desirable for applications than peroxidase-mimicking ones owing to H2O2 can be omitted. In this work, a facile strategy was reported to prepare a series of Co-based bimetallic oxide nanosheets (Co–M–O NSs, M = Fe, Ni, Mn) derived from different isomorphism precursors. Herein, a comprehensive and systematic research of oxidase-like enzymes based on distinctions of elemental surface content and surface state has been undertaken. The porous Co–Mn–O NSs made of Mn-doping Co3O4 can lead to decrease the size of Co3O4 nanoparticle from 20–50 to 20–30 nm, and increase in oxygen vacancy from 20.7% to 21.8%. The Co–Mn–O NSs via the Mn-doping could highly enhanced the performance and efficiency of the oxidase-mimicking, which is 7.5 times than that of Co3O4 and other elements (Ni, Fe) doping Co3O4. Considering the features of Co–Mn–O NSs, a sensitive and selective colorimetric assay for the detection of L-cysteine (L-cys) was established. The system showed a linear absorbance response to L-cys concentrations ranging from 0.8 to 70 μM, with a detection limit of 0.79 μM. This facile and effective fabrication strategy of Co–Mn–O NSs has discovered a highly efficient oxidase-mimicking nanozyme useful in environmental protection, biotechnology, and clinical diagnosis.