Efficient and one-pot synthesis of 2,4,5-trisubstituted imidazoles in the presence of CuI immobilized on LDH coated with 1,3-benzenedisulfonylamide

In this study, a copper iodide catalyst immobilized on layered double hydroxides and covered with a 1,3-benzenedisulfonylamide ligand was successfully synthesized. This catalyst was used for the eco-friendly synthesis of various substituted imidazole derivatives through a one-pot three-component reaction, demonstrating remarkable activity and selectivity. Key benefits of this approach include high product yields, rapid reaction kinetics, low reaction temperature, solvent-free conditions, generation of novel products, and straightforward purification methods. Additionally, the catalyst exhibits simple recyclability (up to 4 cycles), further enhancing its practical appeal.