Ultra-probe sonication assisted greener approach in aqueous hydrotropic media for the synthesis of pyranopyrazole derivatives

In this study, we report a simple, green, effective, and enhanced method for synthesizing pyranopyrazole from four-component condensation of aldehyde, malononitrile, ethyl aceto-acetate, and hydrazine hydrate employing four components in one pot that is multicomponent reactions (MCRs). Multicomponent reactions carried out by using a universal solvent; water has a quality position in organic and green synthesis. By using an aqueous hydrotropic solution and ultra-probe sonication, raising the rate of reaction and getting an excellent yield are the main features of this article. Key features of the current practice include the use of non-hazardous reaction conditions, operational simplicity, and the use of cost-effective initiating substances. The pure product can be isolated easily through simple filtration, eliminating the need for column chromatography. The process yields excellent results and is time-efficient. Additionally, the hydrotrope can be recycled up to five times without significant loss of activity, making it highly beneficial for meeting industrial needs and addressing environmental concerns.