One-pot multicomponent approach towards the synthesis of 5-substituted 1H-tetrazoles using lanthanum (III) nitrate hexahydrate as a catalyst

An intriguing trend in the synthesis of heterocyclic compounds is green chemistry, which involves using environmentally friendly reagents and efficient reactions to suit the demands of the pharmaceutical sector. This study is a part of continuous endeavour to advance novel synthetic approaches for the synthesis of heterocyclic molecules. With lanthanum nitrate hexahydrate as a catalyst, a procedure for the synthesis of tetrazoles was described in this work. The ideal 10% mole ratio of La(NO₃)₃·6H₂O catalyst with DMF solvent produced good yields of the intended products, ranging from 85 to 98%, according to the results. High product yields, cost effectiveness, and operational simplicity are just a few benefits of using La(NO₃)₃·6H₂O as a catalyst in this condensation reaction. The chemical structures of the synthesized tetrazoles were analyzed and characterized using ¹HNMR, ¹³C-NMR, and mass spectra (HRMS).