<p>The silky shark (<i>Carcharhinus falciformis</i>) is a vulnerable pelagic shark species frequently caught as bycatch in tuna and billfish fisheries worldwide. Due to data limitations, conventional stock assessments are generally not feasible, hindering the evaluation of their population status and the effectiveness of potential conservation and management measures (CMMs). In this study, we applied the Ecological Assessment of Sustainable Impacts of Fisheries (EASI-Fish) approach to quantify the cumulative impact of multiple fisheries on the vulnerability status of the Atlantic silky shark and to evaluate the potential effectiveness of 28 alternative CMMs across major fisheries managed by the International Commission for the Conservation of Atlantic Tunas (ICCAT). Results showed high uncertainty in the vulnerability status, ranging from “increasingly vulnerable” under uncertainty-explicit assumptions, to “most vulnerable” under precautionary conditions. Industrial longline fisheries contributed most to cumulative fishing mortality, due to their high spatial overlap with the species’ distribution, while other fisheries (purse seine, gillnet, handline) played smaller, but non-negligible roles. Among the CMMs evaluated, avoidance measures (e.g., static temporal closures) produced the largest reductions in vulnerability. Minimization and remediation measures, such as prohibiting wire-leaders in longliners and implementing best handling and release practices in purse seiners, provided additional but more moderate improvements, particularly when combined, supporting a hierarchical and complementary mitigation approach. The analysis identified critical data gaps, particularly in effort, gear efficiency, and selectivity, where targeted research would most improve future assessments, and demonstrated how a spatially explicit multi-fishery framework can support evidence-based conservation advice for the silky shark in the Atlantic Ocean under uncertainty.</p>