Scholarlink

<p>PANoptosis is a newly proposed theory of the inflammatory programmed cell death (PCD) pathway that is coordinated with key features of pyroptosis, apoptosis and/or necroptosis. It was found to be closely related to immune and inflammation, pathophysiology, cancer and infectious diseases in humans and mammals. However, its role and regulatory mechanism remain unclear currently in fish. Therefore this review introduces the features of PANoptosis, PANoptosome and inflammasome complexes with different sensors and their crosstalk relationships, as well as the molecular regulatory mechanisms of PANoptosis mediated by Toll-like receptors (TLRs), and bacterial secretion system (T3SS/T6SS) induced PANoptosis in macrophage cells. Based on the current evidences of the literature, various aquatic viruses, bacteria, fungi as well as abiotic stress agent induced the cell pyroptosis, apoptosis, and necroptosis, thus linking these three related signaling pathways were well-defined in fish, further summarized and explored the potential mechanism of PANoptosis and function of PANoptosis-related genes (PRGs). The characterization and prospects of novel sensor molecules of PANoptosome were described in fish. Overall, this review provides new ideas for the immune prevention and drug development treatment of infectious disease in aquaculture.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

A review of PANoptosis mechanism: current knowledge on pyroptosis, apoptosis and necroptosis in fish

  • 期刊论文

  • 发表日期：

    2025年6月11日

查看全文
  • Ge Jin,
  • Aijun Lv,
  • Xiucai Hu,
  • Xiaoran Liu,
  • Yixin Chen

摘要

PANoptosis is a newly proposed theory of the inflammatory programmed cell death (PCD) pathway that is coordinated with key features of pyroptosis, apoptosis and/or necroptosis. It was found to be closely related to immune and inflammation, pathophysiology, cancer and infectious diseases in humans and mammals. However, its role and regulatory mechanism remain unclear currently in fish. Therefore this review introduces the features of PANoptosis, PANoptosome and inflammasome complexes with different sensors and their crosstalk relationships, as well as the molecular regulatory mechanisms of PANoptosis mediated by Toll-like receptors (TLRs), and bacterial secretion system (T3SS/T6SS) induced PANoptosis in macrophage cells. Based on the current evidences of the literature, various aquatic viruses, bacteria, fungi as well as abiotic stress agent induced the cell pyroptosis, apoptosis, and necroptosis, thus linking these three related signaling pathways were well-defined in fish, further summarized and explored the potential mechanism of PANoptosis and function of PANoptosis-related genes (PRGs). The characterization and prospects of novel sensor molecules of PANoptosome were described in fish. Overall, this review provides new ideas for the immune prevention and drug development treatment of infectious disease in aquaculture.