<p>The co-pyrolysis of rice husk (RH) and date palm seeds (DS) was conducted with a focus on their physicochemical properties, thermal decomposition behavior, and thermo-kinetic analysis. During co-pyrolysis, synergistic interactions at various blending ratios were also analyzed. Thermal degradation behavior was investigated using a thermogravimetric analyzer, with kinetic analysis performed via the Friedman method and master plot technique. The blended samples exhibited improved fuel properties. As the DS proportion increased, the TG curves exhibited greater mass loss. A pronounced synergistic effect was observed in the 75%DS + 25%RH blend, where a consistently negative deviation in Δ<i>W</i> indicated stronger interactions between the components. The 75%DS + 25%RH blend exhibited consistent negative deviation in activation energy (Δ<i>E</i>_a) values when <i>α</i> exceeded 0.55, signifying a consistently positive synergy during co-pyrolysis. A significant reduction in average activation energy (<i>E</i>_a) was also observed when the DS proportion was 75%, confirming positive synergy. The average pre-exponential factor (<i>A</i>) values for the blends decreased with increasing DS proportion, indicating a reduction in the frequency of molecular collisions. The pyrolysis of all samples generally followed diffusion and order-based mechanisms. Thermodynamic analysis revealed positive change in enthalpy and gibbs free energy values, confirming that additional energy is required for the co-pyrolysis process.</p>