Scholarlink

Purpose: <p>The aim of this study was to evaluate the association between pilonidal sinus disease (PSD) and the subsequent development of depression, addressing an unmet need to examine the psychosocial impact of PSD in a large, representative outpatient cohort in Germany.</p> Methods: <p> A retrospective cohort study was conducted using data from the IQVIA Disease Analyzer database, which contains anonymized medical records from 1,293 general practices across Germany. The study included patients aged ≥ 18 years diagnosed with PSD (ICD-10: L05) between 2005 and 2022, excluding those with pre-existing psychiatric conditions. Propensity score matching (5:1) was performed to pair PSD patients with individuals without PSD. Depression diagnoses (ICD-10: F32, F33) within five years after diagnosis were assessed using Kaplan-Meier curves and Cox regression analysis.</p> Results: <p> A total of 11,245 PSD patients (23% women, mean age 35.3 years) were matched to individuals without PSD. The incidence of depression was higher in PSD patients (11.7%) compared to non-PSD cohort (10.5%) over five years (<i>p</i> &lt; 0.001). PSD was associated with an increased risk of depression (HR: 1.16; 95% CI 1.09–1.24), with stronger associations observed in women (HR: 1.25; 95% CI 1.11–1.41) and patients &gt; 45 years of age (HR: 1.44; 95% CI 1.26–1.64).</p> Conclusion: <p> This study demonstrates a significant association between PSD and depression, highlighting the need for integrated treatment approaches that address both physical and psychological aspects of PSD. Future research should further explore causal mechanisms and develop strategies for prevention and treatment of depression in PSD patients.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Association between pilonidal sinus disease and depression: a population-based cohort study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年9月18日

查看全文
  • Andreas Krieg,
  • Ernst W. Kolbe,
  • Jan H. Wieltsch,
  • Sabine Leerhoff,
  • Sarah Krieg,
  • Karel Kostev

摘要

Purpose:

The aim of this study was to evaluate the association between pilonidal sinus disease (PSD) and the subsequent development of depression, addressing an unmet need to examine the psychosocial impact of PSD in a large, representative outpatient cohort in Germany.

Methods:

A retrospective cohort study was conducted using data from the IQVIA Disease Analyzer database, which contains anonymized medical records from 1,293 general practices across Germany. The study included patients aged ≥ 18 years diagnosed with PSD (ICD-10: L05) between 2005 and 2022, excluding those with pre-existing psychiatric conditions. Propensity score matching (5:1) was performed to pair PSD patients with individuals without PSD. Depression diagnoses (ICD-10: F32, F33) within five years after diagnosis were assessed using Kaplan-Meier curves and Cox regression analysis.

Results:

A total of 11,245 PSD patients (23% women, mean age 35.3 years) were matched to individuals without PSD. The incidence of depression was higher in PSD patients (11.7%) compared to non-PSD cohort (10.5%) over five years (p < 0.001). PSD was associated with an increased risk of depression (HR: 1.16; 95% CI 1.09–1.24), with stronger associations observed in women (HR: 1.25; 95% CI 1.11–1.41) and patients > 45 years of age (HR: 1.44; 95% CI 1.26–1.64).

Conclusion:

This study demonstrates a significant association between PSD and depression, highlighting the need for integrated treatment approaches that address both physical and psychological aspects of PSD. Future research should further explore causal mechanisms and develop strategies for prevention and treatment of depression in PSD patients.