Scholarlink

<p>The native Brazilian fruit, araticum, contains a high amount of phenolics, leading to a strong antioxidant capacity, which makes it a potential source of anticancer agents. This study aimed to use different pre-treatments to improve the efficiency of phenolic extraction and evaluate its bioactive activity. Different pre-treatments, including ultrasound and microwave, were used to increase the extraction yield. Microwave-assisted pre-treatment enhanced both the phenolic yield and antioxidant activity of extracts significantly. Specifically, gallic acid content increased from 131.35 to 156.94&#xa0;mg/100&#xa0;g fresh fruit, while the oxygen radical absorbance capacity doubled, rising from 60.1 to 123.2 µmol TE/g fresh fruit. In addition, the colon cancer cell proliferation assay showed that araticum phenolic extracts, especially with microwave-assisted pre-treatment, have strong antiproliferative capability with low IC<sub>50</sub> value, ranging from 8.06&#xa0;µg/mL to 33.52&#xa0;µg/mL. The possible anticancer targets and inhibition mechanisms have been predicted by PharmMapper and StringDB. The phenolic extract of araticum exhibits strong bioactivities, suggesting its potential as a health-promoting ingredient for chemoprevention.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Phenolic Extracts with Antioxidant and Anticancer Potential from Araticum Fruits (Annona crassiflora Mart.), a Native Brazilian Plant

  • 期刊论文

  • 发表日期：

    2025年6月24日

查看全文
  • Bingqi Chen,
  • Bruna Tischer,
  • Philipus Pangloli,
  • Vermont P. Dia

摘要

The native Brazilian fruit, araticum, contains a high amount of phenolics, leading to a strong antioxidant capacity, which makes it a potential source of anticancer agents. This study aimed to use different pre-treatments to improve the efficiency of phenolic extraction and evaluate its bioactive activity. Different pre-treatments, including ultrasound and microwave, were used to increase the extraction yield. Microwave-assisted pre-treatment enhanced both the phenolic yield and antioxidant activity of extracts significantly. Specifically, gallic acid content increased from 131.35 to 156.94 mg/100 g fresh fruit, while the oxygen radical absorbance capacity doubled, rising from 60.1 to 123.2 µmol TE/g fresh fruit. In addition, the colon cancer cell proliferation assay showed that araticum phenolic extracts, especially with microwave-assisted pre-treatment, have strong antiproliferative capability with low IC50 value, ranging from 8.06 µg/mL to 33.52 µg/mL. The possible anticancer targets and inhibition mechanisms have been predicted by PharmMapper and StringDB. The phenolic extract of araticum exhibits strong bioactivities, suggesting its potential as a health-promoting ingredient for chemoprevention.