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<p>Black corn (<i>Zea mays</i> L.), native to Latin America, has been cultivated for millennia and holds significant cultural and culinary importance. While anthocyanins are well-characterized flavonoids in black corn, acylated derivatives remain insufficiently explored. Here, this study isolated a cyanidin derivative with two malonyl groups from black corncobs, identified as cyanidin-3-<i>O</i>-(3,6-<i>O</i>-dimalonyl-b-D-glucoside) (C3GdM) by mass spectrometry. The effects of C3GdM on the gut microbiota of the elderly and its immunomodulatory activity were examined in vitro. The findings revealed that C3GdM markedly improved gut microbiota composition, promoting beneficial bacteria growth such as <i>Bifidobacterium</i> and <i>Lactobacillus</i> while suppressing harmful bacteria like <i>Escherichia/Shigella</i>. Correspondingly, C3GdM elevated the levels of short-chain fatty acids in the feces of the elderly. Additionally, C3GdM upregulated genes associated with anti-inflammatory responses and antioxidant capacity in the elderly gut microbiota. In lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages, C3GdM reduced nitric oxide, tumor necrosis factor-a and interleukin-6, along with their mRNA expression. Thus, C3GdM is a promising candidate for remodeling gut microbiota in the aging population.</p>

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Isolation and Immunomodulatory Activity of Cyanidin-3-O-(3,6-O-dimalonyl-β-D-glucoside) from the Black Corncob (Zea mays L.) and its Effect on Gut Microbiota in Elderly Feces under Anaerobic Conditions in vitro

  • 期刊论文

  • 发表日期：

    2025年2月10日

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  • Junjie Li,
  • Zhe Zhao,
  • Wenzhuo Liu,
  • Chuanlai Du,
  • Kun Yu,
  • Jianhua Zeng,
  • Qiang Zou,
  • Guijie Chen,
  • Mingchun Wang,
  • Xiaoxiong Zeng,
  • Chunxu Chen

摘要

Black corn (Zea mays L.), native to Latin America, has been cultivated for millennia and holds significant cultural and culinary importance. While anthocyanins are well-characterized flavonoids in black corn, acylated derivatives remain insufficiently explored. Here, this study isolated a cyanidin derivative with two malonyl groups from black corncobs, identified as cyanidin-3-O-(3,6-O-dimalonyl-b-D-glucoside) (C3GdM) by mass spectrometry. The effects of C3GdM on the gut microbiota of the elderly and its immunomodulatory activity were examined in vitro. The findings revealed that C3GdM markedly improved gut microbiota composition, promoting beneficial bacteria growth such as Bifidobacterium and Lactobacillus while suppressing harmful bacteria like Escherichia/Shigella. Correspondingly, C3GdM elevated the levels of short-chain fatty acids in the feces of the elderly. Additionally, C3GdM upregulated genes associated with anti-inflammatory responses and antioxidant capacity in the elderly gut microbiota. In lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages, C3GdM reduced nitric oxide, tumor necrosis factor-a and interleukin-6, along with their mRNA expression. Thus, C3GdM is a promising candidate for remodeling gut microbiota in the aging population.