<p>This work develops a rigorous framework for analyzing ergodicity and mixing in time-inhomogeneous quantum dynamics. It considers quantum evolutions generated by sequences of quantum channels and examines in detail the relationship between the forward and backward dynamics, showing that they are generically nonequivalent in a structurally meaningful way. A central contribution is the adoption of a quantum Markov–Dobrushin approach to quantify mixing, which yields sharpened conditions for convergence rates and for establishing exponential stability of the induced dynamics. The resulting formalism not only extends classical and stationary quantum theories, but also naturally accommodates non-translationally invariant matrix product states, thereby providing a unified interface with experimentally relevant quantum many-body systems.</p>