<p>This review aimed to fill the literature gaps and provide a robust and up-to-date account of the efficacy of mindfulness-based interventions on the quality of life and psychological well-being of individuals with obesity.&#xa0;The prevalence of overweight and obesity are gaining more prominence globally; and several studies have highlighted the effectiveness of mindfulness-based interventions (MBIs) in assisting psychological issues associated with obesity. However, the awareness of MBIs’ impact is yet to be established globally. A systematic review adhering to the PRISMA protocol was conducted, involving searches across five electronic databases. The review encompassed English language publications from January 2013 to July 2023. The inclusion criteria were met by twenty-two eligible randomized controlled trials (RCT) and quasi-experimental studies, involving a total of 1,729 participants. These studies assessed the impact of MBIs on quality of life and various psychological well-being components. The majority of the reviewed studies revealed a positive effect of MBIs on the quality of life and psychological well-being among individuals with obesity. However, more research is needed, particularly studies incorporating an active control group, focusing on Asian populations, and utilizing larger sample sizes, in order to ascertain the effectiveness of MBIs comprehensively.&#xa0;The findings of this review have significant implications and offer directions for the development of MBIs tailored to address weight-related challenges and enhance both physical and psychological well-being.</p>