This work examines the singular nonlinear heat equation \(u_t-\Delta _\alpha u=|x|^{-\gamma } u^q\) on \({\mathbb {R}}_{+}\) , governed by the Bessel operator \(\Delta _\alpha \) , with \(0<q<1,0<\gamma <\gamma _\alpha \) , and non-negative initial data in \({\mathscr {C}}_{*, 0}({\mathbb {R}})\) . Employing fixed-point arguments and semigroup theory, we establish existence, uniqueness, and a comparison principle in \(L_\alpha ^{\infty }\left( {\mathbb {R}}_{+}\right) \) . Solutions exhibit strict positivity and satisfy sharp lower bounds via explicit subsolutions. A critical threshold \(\gamma ^*\) ensures uniqueness for small \(\gamma \) , bridging harmonic analysis and singular PDE theory in Bessel frameworks.