<p>New research indicates that genetic variants related to educational attainment influence individuals’ political participation. This suggests that political inequality of opportunity is partially rooted in an inequality in genetic resources. However, the possibility that these genetic influences are contingent on individuals’ environments, such that they are amplified or reduced by certain environmental characteristics, remains unexplored. Using longitudinal and geo-coded register data for a large sample of genotyped twins in the Swedish Twin Registry, this paper explores whether early-life proximal environments that are conducive to participation modifies the effects of individuals’ education-related genetic resources on voting, as measured by a polygenic index for educational attainment. The results suggest that the level of political engagement, and of SES, both within the family and within the neighbourhood, can reduce the effects of genetic resources on voting. This has implications for how we can direct policy to ameliorate genetic inequalities in political participation.</p>