<p>The abiotic stress response in plants is modulated at various molecular levels, including alternative splicing (AS), which is an important component of the complex regulatory network. AS is regulated by conserved cis-elements, AS-prone splicing factors, and epigenetic changes. Enhanced stress response is the functional implication of the abiotic stress-induced AS events which are exerted through the production of altered proteins and varied ratios of isoforms. For such functions to happen, post-splicing stability of mRNA is crucial, which adds another level of control to otherwise less efficient molecular machinery. This is reflected in the poor correlation between the transcriptome and proteome. ABA-mediated stress response is exerted through altered splicing patterns in the self-regulatory loop. Omics studies, transcriptomics and proteomics, identified the effective AS events and corresponding stress-responsive genes in different plants. They also highlighted the key metabolic and molecular pathways involved. Intron retention is identified as the most common AS event found in plants. These studies provided an indication that increased incidences of AS events are a character associated with sensitive rather than tolerant crops. Systematic studies are required to confirm the observed trends.</p>