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<p>Resistant starch (RS) is a novel nutrient, which has gained attention in the current epidemic era. Allelic variation among rice varieties has been found to influence RS content, prompting an unprecedented research effort. This study conducted a Genome-wide Association Study (GWAS) on 146 rice varieties from Vietnam to identify candidate genes affecting RS content. The RS content across varieties revealed significant variation, highlighting the heterogeneous nature of RS among the samples. Our analysis revealed seven quantitative trait loci (QTLs) distributed across the rice genome. Two strong linkage groups were found in <i>qRS1</i> and <i>qRS12</i> with three and 10 SNPs tightly linked together, respectively. Chromosome 12 exhibited a significant higher RS content in the AAA than other haplotypes. Among the 127 candidate genes, four were transcription factors in which OsbZIP12 is predicted to strongly involve in starch-related pathway. Notably, we found four potential candidate genes including <i>LOC_Os02 g47850, LOC_Os01 g64730.1 LOC_Os12 g18560, LOC_Os01 g12020.</i>1 (or <i>LTPL18</i>) belonging to the gene families with known function involving in starch-pathway. The study uncovers valuable insights into enhancing RS content, offering opportunities for future rice plant breeding to develop strategies with increased RS content, addressing the nutritional challenges associated with chronic metabolic diseases in the epidemic era.</p>

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Genome-Wide Association Studies Reveal Candidate Genes Relating to Resistant Starch Content in Vietnamese Rice Landraces

  • 期刊论文

  • 发表日期：

    2025年4月16日

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  • Huong Thi Mai To,
  • Duy Tran,
  • Nga T. P. Mai

摘要

Resistant starch (RS) is a novel nutrient, which has gained attention in the current epidemic era. Allelic variation among rice varieties has been found to influence RS content, prompting an unprecedented research effort. This study conducted a Genome-wide Association Study (GWAS) on 146 rice varieties from Vietnam to identify candidate genes affecting RS content. The RS content across varieties revealed significant variation, highlighting the heterogeneous nature of RS among the samples. Our analysis revealed seven quantitative trait loci (QTLs) distributed across the rice genome. Two strong linkage groups were found in qRS1 and qRS12 with three and 10 SNPs tightly linked together, respectively. Chromosome 12 exhibited a significant higher RS content in the AAA than other haplotypes. Among the 127 candidate genes, four were transcription factors in which OsbZIP12 is predicted to strongly involve in starch-related pathway. Notably, we found four potential candidate genes including LOC_Os02 g47850, LOC_Os01 g64730.1 LOC_Os12 g18560, LOC_Os01 g12020.1 (or LTPL18) belonging to the gene families with known function involving in starch-pathway. The study uncovers valuable insights into enhancing RS content, offering opportunities for future rice plant breeding to develop strategies with increased RS content, addressing the nutritional challenges associated with chronic metabolic diseases in the epidemic era.