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Purpose <p>To analyze the prevalence of hypertension in patients with acromegaly and assess the impact of acromegaly treatment on blood pressure (BP) outcomes.</p> Methods <p>Retrospective multicenter study of 434 patients with acromegaly surveilled at 25 tertiary hospitals in Spain and Portugal. The cohort was divided into two subgroups: patients with (<i>n</i> = 209) and without (<i>n</i> = 225) hypertension at the time of acromegaly diagnosis.</p> Results <p>Of the 434 patients, 209 (48.2%) had hypertension at the time of acromegaly diagnosis. Patients with acromegaly and hypertension were older and had a higher prevalence of cardiovascular disease and risk factors. A significant BP improvement was observed 3 months after pituitary surgery, with a marked reduction of the SBP (ΔSBP − 5.0mmHg, 95%CI -2.37 to -7.61) and DBP (ΔDBP − 2.2mmHg, 95% CI -0.66 to -3.75). Over a median follow-up of 8.4 years [IQR 4.8–12.8], 16% (<i>n</i> = 35/218) of initially normotensive patients developed hypertension, while 14.1% (<i>n</i> = 27/192) of hypertensive patients achieved hypertension remission. Hypertension remission was more likely in patients taking fewer antihypertensive drugs and with higher IGF1 levels at diagnosis, and in those who had a greater decrease in GH and IGF-1 after surgery.</p> Conclusion <p>At the time of acromegaly diagnosis up to 50% of patients have hypertension, and around 15% of them experience hypertension remission after pituitary surgery. The probability of remission is higher in patients with milder baseline hypertension and higher IGF-1 levels and in those achieving a greater postoperative decrease of GH and IGF-1.</p>

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Prevalence and evolution of hypertension in a large Iberian cohort of patients with acromegaly

  • 期刊论文

  • 发表日期：

    2025年10月25日

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  • Marta Araujo-Castro,
  • Rogelio García-Centeno,
  • Laura González,
  • Ema Lacerda Nobre,
  • Mariana de Griné Severino,
  • Jessica Goi,
  • Marta María Pérez Pena,
  • Edelmiro Menéndez Torre,
  • Claudia Lozano Aida,
  • Iría Novoa-Testa,
  • Fernando Cordido,
  • Raúl Sánchón,
  • Fernando Guerrero-Pérez,
  • Rosario Oliva Rodríguez,
  • Beatriz Rodríguez-Jiménez,
  • María Dolores Ollero García,
  • Ana Irigaray Echarri,
  • Andreu Simó-Servat,
  • María Dolores Moure Rodríguez,
  • Cristina Novo-Rodríguez,
  • María Calatayud,
  • Rocío Villar-Taibo,
  • Ignacio Bernabéu,
  • Carmen Tenorio-Jimenéz,
  • Inmaculada González Molero,
  • Pedro Iglesias,
  • Concepción Blanco,
  • Fernando Vidal-Ostos De Lara,
  • Anna Aulinas,
  • Queralt Asla Roca,
  • Miguel Paja Fano,
  • Antonio Rivera Martínez,
  • Luís Miguel Cardoso,
  • Pedro Marques,
  • Andrea Giustina,
  • Mónica Marazuela,
  • Manel Puig-Domingo,
  • Betina Biagetti

摘要

Purpose

To analyze the prevalence of hypertension in patients with acromegaly and assess the impact of acromegaly treatment on blood pressure (BP) outcomes.

Methods

Retrospective multicenter study of 434 patients with acromegaly surveilled at 25 tertiary hospitals in Spain and Portugal. The cohort was divided into two subgroups: patients with (n = 209) and without (n = 225) hypertension at the time of acromegaly diagnosis.

Results

Of the 434 patients, 209 (48.2%) had hypertension at the time of acromegaly diagnosis. Patients with acromegaly and hypertension were older and had a higher prevalence of cardiovascular disease and risk factors. A significant BP improvement was observed 3 months after pituitary surgery, with a marked reduction of the SBP (ΔSBP − 5.0mmHg, 95%CI -2.37 to -7.61) and DBP (ΔDBP − 2.2mmHg, 95% CI -0.66 to -3.75). Over a median follow-up of 8.4 years [IQR 4.8–12.8], 16% (n = 35/218) of initially normotensive patients developed hypertension, while 14.1% (n = 27/192) of hypertensive patients achieved hypertension remission. Hypertension remission was more likely in patients taking fewer antihypertensive drugs and with higher IGF1 levels at diagnosis, and in those who had a greater decrease in GH and IGF-1 after surgery.

Conclusion

At the time of acromegaly diagnosis up to 50% of patients have hypertension, and around 15% of them experience hypertension remission after pituitary surgery. The probability of remission is higher in patients with milder baseline hypertension and higher IGF-1 levels and in those achieving a greater postoperative decrease of GH and IGF-1.