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Purpose <p>This study aimed to develop a core outcome set (COS) for pituitary surgery to enhance the quality, efficiency and effectiveness of future pituitary adenoma surgery research.</p> Methods <p>Thirty-three outcomes were identified through a systematic review of pituitary adenoma surgery outcomes and a study on patient-reported measures. These were presented in an online survey to healthcare professionals (HCPs), patients and caregivers. In the first round, participants scored each outcome’s importance on a 5-point scale (1—strongly disagree; 5—strongly agree) and could also suggest additional outcomes, which were reviewed and, if appropriate, added to existing domains. In the second round, participants re-scored the updated the list, considering group median and interquartile range scores from the previous round. Outcomes with a median score of 5 were included in the COS. A final live online consensus meeting discussed and voted on borderline outcomes (median scores 3–4).</p> Results <p>The first round received 95 responses (52% HCPs, 48% patients/caregivers). Of the 33 outcomes, 16 received a median score of 5 (strongly agree), three received 4.5 and 14 received 4 (agree). Round two received 87 responses (52% HCPs, 48% patients and caregivers). Of the 33 outcomes, 14 received a median ranking of 5, two received 4.5, 15 received 4 and two received 3 (neutral). The live meeting (attended by 12 participants: 5 HCPs, 6 patients, 1 caregiver), reached consensus on the final COS, which includes 7 domains: short-term surgical outcomes; nasal outcomes; ophthalmic outcomes; endocrine outcomes; quality of life and psychological outcomes; other short-term outcomes; and disease control outcomes.</p> Conclusion <p>We advocate for use of the COS in future pituitary surgery research.</p>

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A core outcome set for pituitary surgery research: an international delphi consensus study

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  • 发表日期：

    2025年7月23日

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  • Alexandra Valetopoulou,
  • Nicola Newall,
  • Danyal Z. Khan,
  • Anouk Borg,
  • Pierre M. G. Bouloux,
  • Fion Bremner,
  • Michael Buchfelder,
  • Simon Cudlip,
  • Neil Dorward,
  • William M. Drake,
  • Juan C. Fernandez-Miranda,
  • Maria Fleseriu,
  • Mathew Geltzeiler,
  • Joy Ginn,
  • Mark Gurnell,
  • Steve Harris,
  • Zane Jaunmuktane,
  • Márta Korbonits,
  • Michael Kosmin,
  • Olympia Koulouri,
  • Hugo Layard Horsfall,
  • Adam N. Mamelak,
  • Richard Mannion,
  • Pat McBride,
  • Ann I. McCormack,
  • Shlomo Melmed,
  • Katherine A. Miszkiel,
  • Gerald Raverot,
  • Thomas Santarius,
  • Theodore H. Schwartz,
  • Inma Serrano,
  • Gabriel Zada,
  • Stephanie E. Baldeweg,
  • Hani J. Marcus,
  • Angelos G. Kolias,
  • Aaron Lawson McLean,
  • Alasdair Mackintosh,
  • Alexandros Boukas,
  • Alison Julia Bryant,
  • Andrew John Blamey,
  • Anita J. Evans,
  • Axel Petzold,
  • Barry Culpin,
  • Benedicte Decoudier,
  • Catherine Bray,
  • Chloe Camoccio,
  • Christopher Allen Lindsay,
  • Claire Briet,
  • Claude Fabien Litre,
  • Colin Victor Betteley,
  • David Edward Perry,
  • David Jonathan Collins,
  • Deborah Hepburn,
  • Deborah Samantha,
  • Eimear Carolan,
  • Dhaval Shukla,
  • Dhruv Parikh,
  • Eduarda Sá-Marta,
  • Francesca Swords,
  • Gemma Leanne Jones,
  • Georgina Wordsworth,
  • Ian Nigel Dibb,
  • Jacek Kunicki,
  • James Alexander,
  • Jamie Lee Prochaska,
  • Jeanette Curran,
  • Jemma Farrell,
  • Jenny Lindsay,
  • Joao Paulo Almeida,
  • John King,
  • Jonathan Chainey,
  • Kanna Gnanalingham,
  • Katy Miller,
  • Laura-Jane Evans,
  • Maddison Broadbent,
  • Mark Gruppetta,
  • Martin Doughty,
  • Martin D. Silveston,
  • McKay Hewison,
  • Mia Littrell,
  • Michelle Fattorini,
  • Mollie Pullin,
  • Pauline Swindells,
  • Peter Johnson Fenwick,
  • Rachael Burnham,
  • Ramez Wadie Kirollos,
  • Rob Laidler,
  • Robert Bryant,
  • Sally-Ann Price,
  • Shelley Jean Pomeroy,
  • Sian Sheppard,
  • Soham Bandyopadhyay,
  • Sophie A. Clarke,
  • Sunita M. C. De Sousa,
  • Thierry Brue,
  • Tsegazeab Laeke,
  • Vanessa Ariza,
  • Varun R. Kshettry

摘要

Purpose

This study aimed to develop a core outcome set (COS) for pituitary surgery to enhance the quality, efficiency and effectiveness of future pituitary adenoma surgery research.

Methods

Thirty-three outcomes were identified through a systematic review of pituitary adenoma surgery outcomes and a study on patient-reported measures. These were presented in an online survey to healthcare professionals (HCPs), patients and caregivers. In the first round, participants scored each outcome’s importance on a 5-point scale (1—strongly disagree; 5—strongly agree) and could also suggest additional outcomes, which were reviewed and, if appropriate, added to existing domains. In the second round, participants re-scored the updated the list, considering group median and interquartile range scores from the previous round. Outcomes with a median score of 5 were included in the COS. A final live online consensus meeting discussed and voted on borderline outcomes (median scores 3–4).

Results

The first round received 95 responses (52% HCPs, 48% patients/caregivers). Of the 33 outcomes, 16 received a median score of 5 (strongly agree), three received 4.5 and 14 received 4 (agree). Round two received 87 responses (52% HCPs, 48% patients and caregivers). Of the 33 outcomes, 14 received a median ranking of 5, two received 4.5, 15 received 4 and two received 3 (neutral). The live meeting (attended by 12 participants: 5 HCPs, 6 patients, 1 caregiver), reached consensus on the final COS, which includes 7 domains: short-term surgical outcomes; nasal outcomes; ophthalmic outcomes; endocrine outcomes; quality of life and psychological outcomes; other short-term outcomes; and disease control outcomes.

Conclusion

We advocate for use of the COS in future pituitary surgery research.