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<p>The <i>Copaifera</i> genus (Fabaceae) is widely used in traditional medicine, especially in the form of oleoresin, for the treatment of inflammatory and infectious disorders. However, other plant parts, particularly the leaves, remain comparatively underexplored despite their considerable pharmacological potential. Therefore, this study aimed to systematically review the available literature regarding the chemical composition and antibacterial activity of leaf extracts from <i>Copaifera</i> species. Literature searches were conducted in Google Scholar, EMBASE, LILACS, PubMed, SciELO, and Scopus databases, including original articles published in Portuguese and English. The search strategy included combinations of descriptors related to <i>Copaifera</i> species, chemical composition, and antibacterial activity. Of the 983 studies initially identified, 11 met the inclusion criteria. The included studies revealed that <i>Copaifera</i> leaf extracts contain a wide variety of secondary metabolites, particularly diterpenes, sesquiterpenes, flavonoids, and pentacyclic triterpenes, which were associated with antibacterial, antioxidant, and anti-inflammatory activities against Gram-positive and Gram-negative bacteria. Non-polar extracts were predominantly associated with terpenoid-rich profiles and antibacterial activity against clinically relevant pathogens. The findings indicate that <i>Copaifera</i> leaf extracts represent a promising and sustainable source of antibacterial bioactive compounds with potential applications in phytotherapeutic and anti-infective formulations. However, the available evidence remains limited by methodological heterogeneity, inconsistent antibacterial assays, limited in vivo validation, and scarce translational studies. Future investigations should prioritize standardized extraction protocols, integrated pharmacological approaches, and in vivo validation to support the therapeutic development of <i>Copaifera</i>-derived compounds.</p>

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Bioactive metabolites and antibacterial activity of Copaifera species: evidence from a systematic review

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月20日

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  • Maria da Conceição Alves da Costa,
  • Maria de Jesus Pereira Gomes,
  • Alessandra Souza dos Santos,
  • Fátima de Cássia Evangelista de Oliveira,
  • Luan Ramalho Pinheiro,
  • Maria Francilene Souza Silva,
  • Ivanilza Moreira de Andrade

摘要

The Copaifera genus (Fabaceae) is widely used in traditional medicine, especially in the form of oleoresin, for the treatment of inflammatory and infectious disorders. However, other plant parts, particularly the leaves, remain comparatively underexplored despite their considerable pharmacological potential. Therefore, this study aimed to systematically review the available literature regarding the chemical composition and antibacterial activity of leaf extracts from Copaifera species. Literature searches were conducted in Google Scholar, EMBASE, LILACS, PubMed, SciELO, and Scopus databases, including original articles published in Portuguese and English. The search strategy included combinations of descriptors related to Copaifera species, chemical composition, and antibacterial activity. Of the 983 studies initially identified, 11 met the inclusion criteria. The included studies revealed that Copaifera leaf extracts contain a wide variety of secondary metabolites, particularly diterpenes, sesquiterpenes, flavonoids, and pentacyclic triterpenes, which were associated with antibacterial, antioxidant, and anti-inflammatory activities against Gram-positive and Gram-negative bacteria. Non-polar extracts were predominantly associated with terpenoid-rich profiles and antibacterial activity against clinically relevant pathogens. The findings indicate that Copaifera leaf extracts represent a promising and sustainable source of antibacterial bioactive compounds with potential applications in phytotherapeutic and anti-infective formulations. However, the available evidence remains limited by methodological heterogeneity, inconsistent antibacterial assays, limited in vivo validation, and scarce translational studies. Future investigations should prioritize standardized extraction protocols, integrated pharmacological approaches, and in vivo validation to support the therapeutic development of Copaifera-derived compounds.