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<p>In recent times, plant-derived exosomes (PDEs) has emerged as “robust cargo” platform to that can enable diversified cross-kingdom interactions and effectual delivery of several therapeutics. These nanoscale vesicles are mainly composed of assorted miRNA types, secondary metabolites, proteins and lipids. The PDEs have recently been well documented to encompass wound healing, anticancer, skin regeneration, and immune modulation effects. Irrespective of these, however successful clinical translation of PDEs is still a challenge due to standardization, scalability, and bioavailability limitations. This perspective therefore reviews recent developments, the key impediments, and potential future directions for PDEs-based therapies in regenerative and personalized medicine.</p>

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Cross-kingdom regulation through plant-derived exosomes: a novel frontier in bioactive molecule delivery

  • 期刊论文

  • 发表日期：

    2026年6月26日

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  • Adnan Amin,
  • SeonJoo Park

摘要

In recent times, plant-derived exosomes (PDEs) has emerged as “robust cargo” platform to that can enable diversified cross-kingdom interactions and effectual delivery of several therapeutics. These nanoscale vesicles are mainly composed of assorted miRNA types, secondary metabolites, proteins and lipids. The PDEs have recently been well documented to encompass wound healing, anticancer, skin regeneration, and immune modulation effects. Irrespective of these, however successful clinical translation of PDEs is still a challenge due to standardization, scalability, and bioavailability limitations. This perspective therefore reviews recent developments, the key impediments, and potential future directions for PDEs-based therapies in regenerative and personalized medicine.