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<p>Huangqin decoction (HQD), a traditional Chinese prescription composed of Scutellariae Radix (Huang-Qin in Chinese), Paeonia Lactiflora (Shao-Yao), Glycyrrhizae Radix et Rhizoma (Gan-Cao), and Jujubae Fructus (Da-Zao), has been used for heat-induced diarrhea (Re-Xie) for over 1800&#xa0;years. Its modern modified pharmaceutical formulation, YIV906, was currently the first traditional Chinese prescriptions botanical medicine to enter the Food and Drug Administration clinical trial phase for cancer treatment. Despite its long history, the modern scientific explorations of its phytochemistry composition and Pharmacological activities still need to be systematically summarized. By analyzing and summarizing the current research of HQD, this review aimed to clarify existing research gaps and propose recommendations for future researches. The search terms “Huangqin decoction” and “Huangqin tang” were utilized to obtain the relevant literature from online databases including Web of Science, PubMed, Google Scholar, SciFinder, and China National Knowledge Infrastructure. Furthermore, traditional medical books in China were also collected. In total, 192 chemical constituents were identified in HQD using analytical methods. The quality evaluation of HQD primarily focused on its chemical fingerprint. In addition, pharmacokinetic studies on HQD centered on the active components present in its constituent herbs. Pharmacological studies showed HQD had anti-ulcerative colitis, anti-cancer, anti-bacterial properties, and regulated metabolism. Its main mechanisms involved signaling pathways like PI3K/AKT/mTOR, miR-185-3p/MLCK/pMLC, and IFN-γ/JAK/ETS, which collectively maintained immune balance, intestinal microbiota, and epithelial barrier integrity. In clinical applications, HQD was commonly used for the treatment of digestive system diseases, cancer, and metabolic syndrome. However, there remained some limitations in the investigation of HQD. Future studies focusing on the elucidation of chemical constituents, the improvement of quality control, and the clarification of functional mechanisms are worthy of exploration.</p>

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Prescription principle, phytochemistry, pharmacological activities and clinical applications of Huangqin decoction: a comprehensive review

  • 期刊论文

  • 发表日期：

    2026年7月14日

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  • Yan Fang,
  • Haizhen Liang,
  • Linlin Lu,
  • Xijie Tian,
  • Yuting Zhang,
  • Junyu Zhang,
  • Zhifeng Dai,
  • Xiaojuan Chen,
  • Juan Song,
  • Tao Su,
  • Zhongqiu Liu,
  • Baiping Ma

摘要

Huangqin decoction (HQD), a traditional Chinese prescription composed of Scutellariae Radix (Huang-Qin in Chinese), Paeonia Lactiflora (Shao-Yao), Glycyrrhizae Radix et Rhizoma (Gan-Cao), and Jujubae Fructus (Da-Zao), has been used for heat-induced diarrhea (Re-Xie) for over 1800 years. Its modern modified pharmaceutical formulation, YIV906, was currently the first traditional Chinese prescriptions botanical medicine to enter the Food and Drug Administration clinical trial phase for cancer treatment. Despite its long history, the modern scientific explorations of its phytochemistry composition and Pharmacological activities still need to be systematically summarized. By analyzing and summarizing the current research of HQD, this review aimed to clarify existing research gaps and propose recommendations for future researches. The search terms “Huangqin decoction” and “Huangqin tang” were utilized to obtain the relevant literature from online databases including Web of Science, PubMed, Google Scholar, SciFinder, and China National Knowledge Infrastructure. Furthermore, traditional medical books in China were also collected. In total, 192 chemical constituents were identified in HQD using analytical methods. The quality evaluation of HQD primarily focused on its chemical fingerprint. In addition, pharmacokinetic studies on HQD centered on the active components present in its constituent herbs. Pharmacological studies showed HQD had anti-ulcerative colitis, anti-cancer, anti-bacterial properties, and regulated metabolism. Its main mechanisms involved signaling pathways like PI3K/AKT/mTOR, miR-185-3p/MLCK/pMLC, and IFN-γ/JAK/ETS, which collectively maintained immune balance, intestinal microbiota, and epithelial barrier integrity. In clinical applications, HQD was commonly used for the treatment of digestive system diseases, cancer, and metabolic syndrome. However, there remained some limitations in the investigation of HQD. Future studies focusing on the elucidation of chemical constituents, the improvement of quality control, and the clarification of functional mechanisms are worthy of exploration.