Scholarlink

<p>The guayule shrub, <i>Parthenium argentatum</i> A. Gray, has a long history of use as an alternative source of natural rubber and latex. However, the resin produced by this shrub, which contains a considerable number of secondary metabolites, has yet to be fully exploited. The most abundant metabolites in guayule resin are the argentatins, which chemically correspond to cycloartenol- and lanostane-type triterpenes, and represent up to 27% of the total resin content. These compounds have significant potential for pharmaceutical development, particularly in relation to their anti-inflammatory, antimicrobial, and antitumorigenic properties. The present study reviews the principal pharmacological and biomedical activities ascribed to the argentatins and demonstrates that minor chemical modifications in their structure through semi-synthesis or biotransformation has the potential to enhance their activity to &gt; tenfold compared with the original compound in approximately 80% of cases. The exploration and utilization of these compounds might increase the commercial utilization of guayule cultivation, facilitating the development of new applications and opportunities for this versatile shrub in the healthcare sector.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The anti-inflammatory and anticancer effects of argentatins are dependent on their chemical structure

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月12日

查看全文
  • Aniela M. Silva-Nolasco,
  • Miguel A. de la Cruz-Morcillo,
  • M. Mercedes García-Martínez,
  • Guayente Latorre,
  • M. Engracia Carrión,
  • Amaya Zalacain,
  • Mariano Martínez-Vázquez,
  • Manuel Carmona

摘要

The guayule shrub, Parthenium argentatum A. Gray, has a long history of use as an alternative source of natural rubber and latex. However, the resin produced by this shrub, which contains a considerable number of secondary metabolites, has yet to be fully exploited. The most abundant metabolites in guayule resin are the argentatins, which chemically correspond to cycloartenol- and lanostane-type triterpenes, and represent up to 27% of the total resin content. These compounds have significant potential for pharmaceutical development, particularly in relation to their anti-inflammatory, antimicrobial, and antitumorigenic properties. The present study reviews the principal pharmacological and biomedical activities ascribed to the argentatins and demonstrates that minor chemical modifications in their structure through semi-synthesis or biotransformation has the potential to enhance their activity to > tenfold compared with the original compound in approximately 80% of cases. The exploration and utilization of these compounds might increase the commercial utilization of guayule cultivation, facilitating the development of new applications and opportunities for this versatile shrub in the healthcare sector.