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<p>The genus <i>Strychnos</i>, belonging to the family Loganiaceae, has been extensively utilized in traditional medicine for the management of neurological disorders, rheumatism, malaria, digestive disorders, and skin diseases. Despite the identification of numerous secondary metabolites in this genus, a comprehensive review consolidating its ethnobotanical uses, phytochemistry, and pharmacological activities remains lacking. The present review aims to provide an updated and systematic compilation of these aspects, thereby establishing a basis for future pharmacological and translational investigations. Literature was collected from ethnomedicinal texts, scientific databases, and other relevant sources following PRISMA 2020 guidelines. A total of 252 phytochemicals have been reported from the genus, including alkaloids, flavonoids, terpenoids, phenolic acids, phytosterols, and other secondary metabolites. Preclinical pharmacological studies indicate that <i>Strychnos</i> species exhibit diverse bioactivities, such as antimicrobial, antiparasitic, anticancer, and anti-inflammatory effects. These findings underscore the value of <i>Strychnos</i> species as sources of bioactive compounds for future drug discovery efforts. Species for which insufficient phytochemical or pharmacological evidence was available were excluded from detailed analysis. Furthermore, structure–activity relationships, mechanisms of action, toxicological evaluation, pharmacokinetic characterization, and in vivo validation remain insufficiently explored and warrant further investigation.</p>

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A review of ethnobotanical uses, phytochemistry, and pharmacology of the genus Strychnos (Loganiaceae)

  • 期刊论文

  • 发表日期：

    2026年6月19日

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  • Deepti Gulati,
  • Yashasvi Singh

摘要

The genus Strychnos, belonging to the family Loganiaceae, has been extensively utilized in traditional medicine for the management of neurological disorders, rheumatism, malaria, digestive disorders, and skin diseases. Despite the identification of numerous secondary metabolites in this genus, a comprehensive review consolidating its ethnobotanical uses, phytochemistry, and pharmacological activities remains lacking. The present review aims to provide an updated and systematic compilation of these aspects, thereby establishing a basis for future pharmacological and translational investigations. Literature was collected from ethnomedicinal texts, scientific databases, and other relevant sources following PRISMA 2020 guidelines. A total of 252 phytochemicals have been reported from the genus, including alkaloids, flavonoids, terpenoids, phenolic acids, phytosterols, and other secondary metabolites. Preclinical pharmacological studies indicate that Strychnos species exhibit diverse bioactivities, such as antimicrobial, antiparasitic, anticancer, and anti-inflammatory effects. These findings underscore the value of Strychnos species as sources of bioactive compounds for future drug discovery efforts. Species for which insufficient phytochemical or pharmacological evidence was available were excluded from detailed analysis. Furthermore, structure–activity relationships, mechanisms of action, toxicological evaluation, pharmacokinetic characterization, and in vivo validation remain insufficiently explored and warrant further investigation.