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<p>Alzheimer’s disease (AD) is a chronic, progressive neurodegenerative disorder marked by cognitive decline, memory impairment, and behavioural changes, ultimately leading to mortality. With over 45 million cases globally, the prevalence of AD is projected to triple by 2050, posing a significant healthcare challenge due to the absence of curative therapies. The plant kingdom is a rich source of bioactive metabolites with neuroprotective properties. Recent studies have highlighted the potential of various phytochemicals in modulating key molecular mechanisms involved in AD pathogenesis, including reducing oxidative stress, inhibiting aberrant glial activation to attenuate neuroinflammation, promoting amyloid-beta (Aβ) clearance, inhibiting cholinesterase activity, and enhancing acetylcholine levels. This review provides an in-depth analysis of secondary metabolites from plants with promising anti-Alzheimer’s potential, emphasizing their mechanisms of action, challenges, and future research directions. The findings aim to promote further investigation into phytochemical-based interventions for AD management.</p> Graphical abstract <p></p>

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Phytometabolites as therapeutics for Alzheimer’s disease: mechanistic insights into neuroprotection and amyloid clearance

  • 期刊论文

  • 发表日期：

    2026年5月6日

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  • Priyanka Sharma,
  • Aatif Subhan,
  • Samriti Saklania,
  • Suresh Thareja

摘要

Alzheimer’s disease (AD) is a chronic, progressive neurodegenerative disorder marked by cognitive decline, memory impairment, and behavioural changes, ultimately leading to mortality. With over 45 million cases globally, the prevalence of AD is projected to triple by 2050, posing a significant healthcare challenge due to the absence of curative therapies. The plant kingdom is a rich source of bioactive metabolites with neuroprotective properties. Recent studies have highlighted the potential of various phytochemicals in modulating key molecular mechanisms involved in AD pathogenesis, including reducing oxidative stress, inhibiting aberrant glial activation to attenuate neuroinflammation, promoting amyloid-beta (Aβ) clearance, inhibiting cholinesterase activity, and enhancing acetylcholine levels. This review provides an in-depth analysis of secondary metabolites from plants with promising anti-Alzheimer’s potential, emphasizing their mechanisms of action, challenges, and future research directions. The findings aim to promote further investigation into phytochemical-based interventions for AD management.

Graphical abstract