<p>For centuries, plants have served as the foundation of folk herbal remedies for treating a wide range of ailments, inspiring the discovery and development of new drugs. India boasts a rich tradition of utilizing medicinal plants for therapeutic purposes, a legacy spanning millennia and deeply embedded within its diverse cultural tapestry. In light of recent advancements in molecular targets based on proteins, there is an increasing demand for fresh chemical diversity in screening processes. Natural products continue to be crucial in meeting this demand through ongoing exploration of global biodiversity, much of which remains untapped. While drug discovery from medicinal plants remains a significant avenue for finding novel therapeutic leads, several challenges persist, including the identification and implementation of suitable high-throughput screening assays, as well as the scaling up of bioactive molecule production and procurement of plant materials. Addressing these challenges requires collaborative efforts across multiple disciplines, spanning national and global partnerships in the realms of design, synthesis, discovery, and drug development techniques. The present review paper focus on the advancement in the traditional uses of medicinal plant based on indigenous knowledge through explaining the mechanisms of modern drug development using various approaches such as omics technologies, computational biology, CRISPR/Cas9 system, artificial intelligence (AI) and efficient drug delivery by nanoparticle, hydrogels, phytosomes, self-emulsifying drug delivery systems (DEDDS), etc.</p>

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Ethnopharmacological exploration of Indian medicinal plants: from traditional knowledge to modern medicine

  • Indrajeet Kumar,
  • Sachin Kumar Vishwakarma,
  • Prince Kumar Singh,
  • Umesh Kumar,
  • Rahul Prasad Singh,
  • Parvati Madheshiya,
  • Akanksha Dwivedi,
  • Priyanka Singh,
  • Rajesh Kumar Sharma

摘要

For centuries, plants have served as the foundation of folk herbal remedies for treating a wide range of ailments, inspiring the discovery and development of new drugs. India boasts a rich tradition of utilizing medicinal plants for therapeutic purposes, a legacy spanning millennia and deeply embedded within its diverse cultural tapestry. In light of recent advancements in molecular targets based on proteins, there is an increasing demand for fresh chemical diversity in screening processes. Natural products continue to be crucial in meeting this demand through ongoing exploration of global biodiversity, much of which remains untapped. While drug discovery from medicinal plants remains a significant avenue for finding novel therapeutic leads, several challenges persist, including the identification and implementation of suitable high-throughput screening assays, as well as the scaling up of bioactive molecule production and procurement of plant materials. Addressing these challenges requires collaborative efforts across multiple disciplines, spanning national and global partnerships in the realms of design, synthesis, discovery, and drug development techniques. The present review paper focus on the advancement in the traditional uses of medicinal plant based on indigenous knowledge through explaining the mechanisms of modern drug development using various approaches such as omics technologies, computational biology, CRISPR/Cas9 system, artificial intelligence (AI) and efficient drug delivery by nanoparticle, hydrogels, phytosomes, self-emulsifying drug delivery systems (DEDDS), etc.