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<p><i>Curcumae Rhizoma</i> is obtained from the dried rhizomes of <i>Curcuma phaeocaulis</i> Valeton, <i>Curcuma kwangsiensis</i> S. G. Lee et C. F. Ling and <i>Curcuma wenyujin</i> Y. H. Chen et C. Ling. It is usually used to treat dysmenorrhea, amenorrhea, irregular menstruation, pelvic blood stasis, abdominal epigastric tumor, arrhythmia, coronary heart disease, stroke, indigestion, gastritis, etc. Sesquiterpenoid and diarylheptanoid compounds are the main components in <i>Curcumae Rhizoma</i>. In this paper, the chemical structure and skeleton characteristics of 319 compounds were systematically summarized since 2001, including 263 terpenoids (1–263) and 55 diarylheptanoids (264–318). Among these, sesquiterpenoids are the most (24–252), mainly including guaiacane-type, eudesane-type, germarane-type, calabane-ype, etc. In addition, we also summarized the pharmacological activities of compounds isolated from <i>Curcumae Rhizoma</i>. The biosynthesis of chemical components from <i>Curcumae Rhizoma</i> was summarized for the first time. This review also provides significant reference for the structural analysis, biogenic pathways, and pharmacological activities of the compounds in <i>Curcumae Rhizoma</i>.</p> Graphical abstract <p></p>

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Research progress on chemical constituents from Curcumae Rhizoma, and their pharmacological activity and biosynthesis

  • 期刊论文

  • 发表日期：

    2026年2月13日

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  • Qingqing Zhang,
  • Yang Xu,
  • Xiaofen Liu,
  • Xurong Miao,
  • Hua Li,
  • Lixia Chen

摘要

Curcumae Rhizoma is obtained from the dried rhizomes of Curcuma phaeocaulis Valeton, Curcuma kwangsiensis S. G. Lee et C. F. Ling and Curcuma wenyujin Y. H. Chen et C. Ling. It is usually used to treat dysmenorrhea, amenorrhea, irregular menstruation, pelvic blood stasis, abdominal epigastric tumor, arrhythmia, coronary heart disease, stroke, indigestion, gastritis, etc. Sesquiterpenoid and diarylheptanoid compounds are the main components in Curcumae Rhizoma. In this paper, the chemical structure and skeleton characteristics of 319 compounds were systematically summarized since 2001, including 263 terpenoids (1–263) and 55 diarylheptanoids (264–318). Among these, sesquiterpenoids are the most (24–252), mainly including guaiacane-type, eudesane-type, germarane-type, calabane-ype, etc. In addition, we also summarized the pharmacological activities of compounds isolated from Curcumae Rhizoma. The biosynthesis of chemical components from Curcumae Rhizoma was summarized for the first time. This review also provides significant reference for the structural analysis, biogenic pathways, and pharmacological activities of the compounds in Curcumae Rhizoma.

Graphical abstract