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Abstract <p>Traditional Chinese medicine (TCM) processing is a unique pharmaceutical technique in China. It is characterized by methodological complexity, procedural diversity, and important scientific implications. TCM processing plays a critical role in the TCM system. Understanding the chemical composition changes before and after the processing of TCM has remained a critical research focus. These compositional shifts are pivotal to elucidating the mechanistic basis of TCM processing and enhancing its clinical efficacy. The application of advanced analytical techniques, such as spectrometry and chromatography, has significantly contributed to these efforts. These methodologies have provided a robust foundation for characterizing chemical transformations of TCM preparation. This review summarizes current research progress on the changes in material basis associated with TCM processing. Particular emphasis is placed on in vitro and in vivo analytical methods. The review aims to offer new insights and useful references to support the chemical studies of TCM processing.</p> Graphical abstract <p></p>

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Research progress on the chemical composition changes of traditional Chinese medicine before and after processing based on modern analytical techniques

  • 期刊论文

  • 发表日期：

    2025年8月21日

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  • Xuelin Zong,
  • Yun Shi,
  • Ying Zhao,
  • Yuman Li,
  • Rong Guo,
  • Gengyi Shang,
  • Chenfeng Zhang,
  • Jinyang Shen,
  • Xun Gao,
  • Weidong Li,
  • Kunming Qin

摘要

Abstract

Traditional Chinese medicine (TCM) processing is a unique pharmaceutical technique in China. It is characterized by methodological complexity, procedural diversity, and important scientific implications. TCM processing plays a critical role in the TCM system. Understanding the chemical composition changes before and after the processing of TCM has remained a critical research focus. These compositional shifts are pivotal to elucidating the mechanistic basis of TCM processing and enhancing its clinical efficacy. The application of advanced analytical techniques, such as spectrometry and chromatography, has significantly contributed to these efforts. These methodologies have provided a robust foundation for characterizing chemical transformations of TCM preparation. This review summarizes current research progress on the changes in material basis associated with TCM processing. Particular emphasis is placed on in vitro and in vivo analytical methods. The review aims to offer new insights and useful references to support the chemical studies of TCM processing.

Graphical abstract