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<p>Acquired brain injury (ABI), an injury resulting from a direct lesion of the brain, encompasses a spectrum of conditions, including traumatic brain injury, cerebral hemorrhage, cerebral ischemia, brain tumor, etc. Clinical interventions for these diseases remain limited. Intervention for the primary injury is still lacking, while the secondary damage holds potential for improvement. Ferroptosis has emerged as a significant contributor to the secondary injury. Recent investigations have progressively unraveled the mechanistic underpinnings of ferroptosis in ABI. Natural compounds have recently exhibited promising therapeutic potential in ABI by effectively mitigating brain damage associated with dysregulated iron metabolism. Therefore, this comprehensive review elucidates the therapeutic potential of natural compounds in treating ABI and their regulatory mechanisms involving ferroptosis. These findings provide valuable insights for guiding clinical interventions and hold promise for improving the prognosis of patients with ABI.</p>

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Regulation of ferroptosis with natural compounds: potential applications in the treatment of acquired brain injury

  • 期刊论文

  • 发表日期：

    2025年8月11日

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  • Haonan Zhu,
  • Peidi Li,
  • Zherui Xing,
  • Bo Yang,
  • Fei Zheng,
  • Zhe Yu,
  • Wei Zhang,
  • Xueping Yang,
  • Jiekun Luo,
  • Tao Tang,
  • Yang Wang,
  • En Hu,
  • Teng Li

摘要

Acquired brain injury (ABI), an injury resulting from a direct lesion of the brain, encompasses a spectrum of conditions, including traumatic brain injury, cerebral hemorrhage, cerebral ischemia, brain tumor, etc. Clinical interventions for these diseases remain limited. Intervention for the primary injury is still lacking, while the secondary damage holds potential for improvement. Ferroptosis has emerged as a significant contributor to the secondary injury. Recent investigations have progressively unraveled the mechanistic underpinnings of ferroptosis in ABI. Natural compounds have recently exhibited promising therapeutic potential in ABI by effectively mitigating brain damage associated with dysregulated iron metabolism. Therefore, this comprehensive review elucidates the therapeutic potential of natural compounds in treating ABI and their regulatory mechanisms involving ferroptosis. These findings provide valuable insights for guiding clinical interventions and hold promise for improving the prognosis of patients with ABI.