Scholarlink

<p>Phytochemicals, particularly phenolic compounds and terpenes from plants, have gained attention as sources for novel antimicrobial agents. This review examined their potential against pathogenic free-living amoebae (FLA): <i>Naegleria fowleri</i>, <i>Acanthamoeba</i> spp., and <i>Balamuthia mandrillaris</i>. These FLAs cause severe, often fatal (95–98% mortality), infections of the central nervous system, eyes, and skin, with substantial challenges in diagnosis and treatment. The review highlights phytochemicals with amoebicidal activity, for instance, apigenin (IC50 6.59&#xa0;µg/mL) and syringic acid (IC50 22.91&#xa0;µg/mL) against <i>Acanthamoeba castellanii</i>, and nordihydroguaiaretic acid (IC50 37&#xa0;µM) against <i>Naegleria fowleri</i>. Given these persistent therapeutic challenges, developing new agents is critical. While phytochemicals show significant promise, translating this to clinical use requires addressing key research gaps. Future research must prioritize: (1) isolating and characterizing active compounds from promising extracts; (2) exploring synergistic interactions between these compounds to improve efficacy; and (3) advancing the most effective candidates through comprehensive preclinical research, including in vivo efficacy and safety evaluations, to develop effective phytomedicines against these devastating pathogens.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Phytochemicals as promising agents against pathogenic free-living amoebas

  • 期刊论文

  • 发表日期：

    2025年7月14日

查看全文
  • Erick P. Gutiérrez-Grijalva,
  • Laura A. Contreras-Angulo,
  • Marilyn Shomara Criollo-Mendoza,
  • J. Basilio Heredia,
  • Jaime López-Cervantes,
  • Dalia Isabel Sánchez-Machado,
  • Jose Reyes Gonzalez-Galaviz,
  • Libia Zulema Rodriguez-Anaya

摘要

Phytochemicals, particularly phenolic compounds and terpenes from plants, have gained attention as sources for novel antimicrobial agents. This review examined their potential against pathogenic free-living amoebae (FLA): Naegleria fowleri, Acanthamoeba spp., and Balamuthia mandrillaris. These FLAs cause severe, often fatal (95–98% mortality), infections of the central nervous system, eyes, and skin, with substantial challenges in diagnosis and treatment. The review highlights phytochemicals with amoebicidal activity, for instance, apigenin (IC50 6.59 µg/mL) and syringic acid (IC50 22.91 µg/mL) against Acanthamoeba castellanii, and nordihydroguaiaretic acid (IC50 37 µM) against Naegleria fowleri. Given these persistent therapeutic challenges, developing new agents is critical. While phytochemicals show significant promise, translating this to clinical use requires addressing key research gaps. Future research must prioritize: (1) isolating and characterizing active compounds from promising extracts; (2) exploring synergistic interactions between these compounds to improve efficacy; and (3) advancing the most effective candidates through comprehensive preclinical research, including in vivo efficacy and safety evaluations, to develop effective phytomedicines against these devastating pathogens.