Scholarlink

<p>The <i>Pistacia</i> genus is a rich source of bioactive compounds, including flavonoids, polyphenolics, tannins, and terpenoids, which contribute to its antimicrobial, antioxidant, anti-inflammatory, and anticancer properties. These phytochemicals exert their therapeutic effects through various mechanisms, such as apoptosis induction in cancer cells, disruption of bacterial cell membranes, and modulation of inflammatory pathways. Despite their promising pharmacological activities, <i>Pistacia</i> extracts face a few limitations, including poor bioavailability, low aqueous solubility, and rapid degradation, which restrict their clinical and industrial applications. To overcome these challenges, encapsulation into nanosystems was extensively explored. This review highlights the integration of <i>Pistacia</i> extracts into various nanocarriers, including lipid-based and polymeric nanoparticles, nanoemulsions, nanofibers, silica nanoparticles,&#xa0;and chitosan-based nanosystems, which were employed in diverse biomedical and food applications. Nanoformulations of <i>Pistacia</i> extracts have demonstrated enhanced antioxidant capacity, controlled release, selective cytotoxicity against cancer cells, and improved antimicrobial efficacy, offering promising strategies for cancer therapy, wound healing, and food preservation. Despite these advancements, key challenges remain, including scalability, regulatory approval, and long-term stability. Additionally, the European Committee on Herbal Medicinal Products (HMPC) recognized <i>Pistacia lentiscus</i> resins for medicinal use emphasizing the need for regulatory alignment of nanoformulated <i>Pistacia</i> extracts. This review underscores the potential of nanotechnology in unlocking the full potential of <i>Pistacia</i> extracts, paving the way for future clinical translation and commercialization.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Enhancing the therapeutic potential of Pistacia extracts: a review of nanocarrier-based strategies

  • 期刊论文

  • 发表日期：

    2025年6月17日

查看全文
  • Obaydah Abd Alkader Alabrahim,
  • Hassan Mohamed El-Said Azzazy

摘要

The Pistacia genus is a rich source of bioactive compounds, including flavonoids, polyphenolics, tannins, and terpenoids, which contribute to its antimicrobial, antioxidant, anti-inflammatory, and anticancer properties. These phytochemicals exert their therapeutic effects through various mechanisms, such as apoptosis induction in cancer cells, disruption of bacterial cell membranes, and modulation of inflammatory pathways. Despite their promising pharmacological activities, Pistacia extracts face a few limitations, including poor bioavailability, low aqueous solubility, and rapid degradation, which restrict their clinical and industrial applications. To overcome these challenges, encapsulation into nanosystems was extensively explored. This review highlights the integration of Pistacia extracts into various nanocarriers, including lipid-based and polymeric nanoparticles, nanoemulsions, nanofibers, silica nanoparticles, and chitosan-based nanosystems, which were employed in diverse biomedical and food applications. Nanoformulations of Pistacia extracts have demonstrated enhanced antioxidant capacity, controlled release, selective cytotoxicity against cancer cells, and improved antimicrobial efficacy, offering promising strategies for cancer therapy, wound healing, and food preservation. Despite these advancements, key challenges remain, including scalability, regulatory approval, and long-term stability. Additionally, the European Committee on Herbal Medicinal Products (HMPC) recognized Pistacia lentiscus resins for medicinal use emphasizing the need for regulatory alignment of nanoformulated Pistacia extracts. This review underscores the potential of nanotechnology in unlocking the full potential of Pistacia extracts, paving the way for future clinical translation and commercialization.