<p>The increased use of chemical, biological, radiological, and nuclear (CBRN) agents in various aspects of human life, such as industries, research facilities, medical facilities, agriculture, and nuclear power plants, has increased the risk of dermal contamination. Therefore, it is the need of hour to develop effective, and non-toxic dermal decontamination moieties. Although there are synthetic formulations available against individual contaminants, they are not effective against a broad range of contaminants and may themselves be toxic. The human race has used herbal leads and associated formulations since its inception primarily because of their natural origins and non-toxic in nature. The current review is focused on the identification of plant-based decontaminants that can be used as an alternative to synthetic decontaminants. The working of commercially available decontaminants are based on mechanisms such as adsorption, chelation, oxidation, emulsification, hydrolysis, and reduction. Many plants show these properties; therefore, it is pertinent to expect that these plants may decontaminate a broad range of CBRN contaminants. Therefore, a broad screening of the plants is performed based on the above-mentioned properties. It was found that there are many plants available that have activities relevant for decontamination purposes and hence can be used alone or in polyherbal form. The potential impact of this research is significant, as it could revolutionize the field of decontamination. These plants/herbal ingredients may be used both for human and material decontamination.</p>