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<p>Cuminaldehyde (CUM) is a bioactive compound majorly present in the seeds of <i>Cuminum cyminum.</i> The plant <i>C. cyminum</i> is the hub of numerous bioactive compounds that have various pharmacological significance, and CUM is one of them. Various extraction and purification methodologies have been developed to isolate CUM from plant origins and study its effectiveness in treating a range of disorders. The present study comprises recent pharmacological properties of CUM that have been reported to exert various pharmacological properties, such as anti-microbial, anti-neurodegenerative, anti-inflammatory, anti-cancer, anti-diabetic, anti-obesity, and anti-parasitic. Additionally, CUM improved the effects of other anti-microbial drugs, including vancomycin, tobramycin, and ciprofloxacin. Similarly, we have outlined many targeted delivery systems that have been used to deliver CUM to the disease-specific target system, such as microemulsions, inclusion complexes, mesoporous silica nanoparticles, and smart hydrogel. The absorption, distribution, metabolism, excretion, and toxicity (ADMET) profiles of CUM have also been predicted using SwissADME and Deep-PK. Moreover, this review provides a complete overview of CUM’s isolation and purification processes, its synthetic analogues, biological activities with mechanisms of action, novel delivery systems, and pK-pD profile with <i>in silico</i> ADMET parameters. All of this will be beneficial for researchers assessing CUM’s pre-clinical and clinical outcomes in the near future.</p> Graphical Abstract <p></p>

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Exploring the therapeutic potentials of cuminaldehyde: a comprehensive review of biological activities, mechanisms, and novel delivery systems

  • 期刊论文

  • 发表日期：

    2025年1月22日

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  • Abhik Paul,
  • Sai Satyaprakash Mishra,
  • Avik Maji,
  • Ajeya Samanta,
  • Sourin Nahar,
  • Tapan Kumar Maity

摘要

Cuminaldehyde (CUM) is a bioactive compound majorly present in the seeds of Cuminum cyminum. The plant C. cyminum is the hub of numerous bioactive compounds that have various pharmacological significance, and CUM is one of them. Various extraction and purification methodologies have been developed to isolate CUM from plant origins and study its effectiveness in treating a range of disorders. The present study comprises recent pharmacological properties of CUM that have been reported to exert various pharmacological properties, such as anti-microbial, anti-neurodegenerative, anti-inflammatory, anti-cancer, anti-diabetic, anti-obesity, and anti-parasitic. Additionally, CUM improved the effects of other anti-microbial drugs, including vancomycin, tobramycin, and ciprofloxacin. Similarly, we have outlined many targeted delivery systems that have been used to deliver CUM to the disease-specific target system, such as microemulsions, inclusion complexes, mesoporous silica nanoparticles, and smart hydrogel. The absorption, distribution, metabolism, excretion, and toxicity (ADMET) profiles of CUM have also been predicted using SwissADME and Deep-PK. Moreover, this review provides a complete overview of CUM’s isolation and purification processes, its synthetic analogues, biological activities with mechanisms of action, novel delivery systems, and pK-pD profile with in silico ADMET parameters. All of this will be beneficial for researchers assessing CUM’s pre-clinical and clinical outcomes in the near future.

Graphical Abstract