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Background <p>The <i>In Vitro</i> Permeation Test (IVPT) is a valuable tool for the study of topical pharmacokinetics of dermatologic formulations. A 45&#xa0;year retrospective analysis was performed on archived percutaneous absorption data from various corticosteroids found in the author’s files.</p> Objective <p>The objective was to collate archived data on the relative bioavailability of topical corticosteroids from 15 steroids found in 62 formulations using the <i>in vitro</i> permeation test (IVPT) and the&#xa0;finite dose&#xa0;human cadaver skin model. Studies were conducted with and without occlusion, at different active ingredient concentrations and dose durations. Select steroids also had evaluations with vasoconstriction, and stratum corneum content by tape stripping.</p> Results <p>The percutaneous absorption of topical corticosteroids is highly dependent on formulation, but less so on steroid concentration within the formulation, and whether the applied dose is occluded or not occluded. In addition vasoconstriction does not necessarily correlate with steroid permeation.</p> Conclusions <p>The IVPT method demonstrates that it can characterize the topical pharmacokinetics of topical corticosteroids. Overall, this retrospective analysis of data supports the value of the IVPT method for evaluating percutaneous absorption pharmacokinetics for topical therapeutic agents.</p>

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Cutaneous Bioavailability of Corticosteroids from Topical Formulations: a Retrospective Analysis of Data from In Vitro Permeation Testing (IVPT) and In Vivo Assessments

  • 期刊论文

  • 发表日期：

    2026年5月5日

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  • Paul A. Lehman,
  • Thomas J. Franz

摘要

Background

The In Vitro Permeation Test (IVPT) is a valuable tool for the study of topical pharmacokinetics of dermatologic formulations. A 45 year retrospective analysis was performed on archived percutaneous absorption data from various corticosteroids found in the author’s files.

Objective

The objective was to collate archived data on the relative bioavailability of topical corticosteroids from 15 steroids found in 62 formulations using the in vitro permeation test (IVPT) and the finite dose human cadaver skin model. Studies were conducted with and without occlusion, at different active ingredient concentrations and dose durations. Select steroids also had evaluations with vasoconstriction, and stratum corneum content by tape stripping.

Results

The percutaneous absorption of topical corticosteroids is highly dependent on formulation, but less so on steroid concentration within the formulation, and whether the applied dose is occluded or not occluded. In addition vasoconstriction does not necessarily correlate with steroid permeation.

Conclusions

The IVPT method demonstrates that it can characterize the topical pharmacokinetics of topical corticosteroids. Overall, this retrospective analysis of data supports the value of the IVPT method for evaluating percutaneous absorption pharmacokinetics for topical therapeutic agents.