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<p>The physicochemical properties of polysaccharides from leaves of the common horse chestnut (<i>Aesculus hippocastanum</i> L.) grown in the Republic of Uzbekistan were isolated and studied. Water-soluble polysaccharides were extracted in 13.5% yield from crushed horse chestnut leaves. The IR spectra of the obtained samples revealed signals and absorption regions characteristic of polysaccharides. Water-soluble polysaccharides from horse chestnut leaves at doses of 25 and 50 mg/kg induced humoral immunity when administered intragastrically. A study of the effect of water-soluble polysaccharides on cellular immunity showed that they reliably stimulated the formation of an antigen-specific T-lymphocyte clone and had an efficacy at a dose of 50 mg/kg like that of the reference drug Immunal. Water-soluble polysaccharides at a dose of 50 mg/kg had a stimulating effect on the central immune organ (thymus), the peripheral organ (lymph nodes), and on cellular immunity, leading to an increase in the number of nucleated cells in the thymus by 1.8 – 2.0 times, the spleen by 1.1 – 1.7 times, the lymph nodes by 2.9 – 3.9 times, bone marrow, and macrophages in the peritoneal fluid.</p>

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Isolation and Biological Activity of Polysaccharides from Horse Chestnut Leaves (Aesculus hippocastanum L.)

  • 期刊论文

  • 发表日期：

    2026年2月1日

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  • A. V. Filatov,
  • L. B. Azimova,
  • A. S. Turaev,
  • D. G. Abdugafurova

摘要

The physicochemical properties of polysaccharides from leaves of the common horse chestnut (Aesculus hippocastanum L.) grown in the Republic of Uzbekistan were isolated and studied. Water-soluble polysaccharides were extracted in 13.5% yield from crushed horse chestnut leaves. The IR spectra of the obtained samples revealed signals and absorption regions characteristic of polysaccharides. Water-soluble polysaccharides from horse chestnut leaves at doses of 25 and 50 mg/kg induced humoral immunity when administered intragastrically. A study of the effect of water-soluble polysaccharides on cellular immunity showed that they reliably stimulated the formation of an antigen-specific T-lymphocyte clone and had an efficacy at a dose of 50 mg/kg like that of the reference drug Immunal. Water-soluble polysaccharides at a dose of 50 mg/kg had a stimulating effect on the central immune organ (thymus), the peripheral organ (lymph nodes), and on cellular immunity, leading to an increase in the number of nucleated cells in the thymus by 1.8 – 2.0 times, the spleen by 1.1 – 1.7 times, the lymph nodes by 2.9 – 3.9 times, bone marrow, and macrophages in the peritoneal fluid.