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<p>The aim of the present work was to investigate the general toxicity, local irritant effects, and antiallergic activity of a transdermal therapeutic system (TTS) based on micellar desloratadine. The desloratadine-containing TTS exhibited an antihistamine effect for 14 days in an allergic reaction model and prevented the development of allergic rhinitis when rats were sensitized with ovalbumin. A study of the general toxicity and local irritant effects of the TTS compared to Vaseline showed that the TTS affected the biochemical and hematological parameters in rats less than the reference drug Vaseline. Application of the TTS to the skin of rats for 14 consecutive days had no significant effect on respiratory or cardiovascular functions. The TTS did not cause local irritation with repeated skin application and did not alter the skin morphology.</p>

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Antiallergic Activity and Safety of a Transdermal Therapeutic System Based on Histamine H1-Receptor Blockers

  • 期刊论文

  • 发表日期：

    2026年2月1日

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  • V. A. Ageev,
  • A. V. Zaborovsky,
  • L. A. Tararina,
  • E. V. Markushova,
  • A. D. Sinichkina,
  • A. K. Fomenko,
  • D. V. Kurkin,
  • A. E. Pyanzina,
  • V. I. Shlyapkina,
  • M. K. Devkota,
  • D. V. Yunina,
  • D. N. Andreev,
  • O. A. Kulikov,
  • N. A. Pyataev

摘要

The aim of the present work was to investigate the general toxicity, local irritant effects, and antiallergic activity of a transdermal therapeutic system (TTS) based on micellar desloratadine. The desloratadine-containing TTS exhibited an antihistamine effect for 14 days in an allergic reaction model and prevented the development of allergic rhinitis when rats were sensitized with ovalbumin. A study of the general toxicity and local irritant effects of the TTS compared to Vaseline showed that the TTS affected the biochemical and hematological parameters in rats less than the reference drug Vaseline. Application of the TTS to the skin of rats for 14 consecutive days had no significant effect on respiratory or cardiovascular functions. The TTS did not cause local irritation with repeated skin application and did not alter the skin morphology.