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<p>Isotopically labeled compounds have played and continue to play a significant role in biological research. A new stage in their use is currently emerging, unique in that deuterium compounds are being offered as pharmaceuticals. The chemistry of isotopically labeled compounds is evolving into medicinal chemistry. The synthesis of deuterium-based drugs is becoming a pressing issue. The present review examines various approaches to producing deuterium drugs such as deuterium introduction by heterogeneous isotope exchange using D<sub>2</sub> and D<sub>2</sub>O; synthesis of labeled compounds using labeled reagents, labeled precursors, and homogeneous catalysts; and deuterium introduction using chemical synthesis.</p>

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Deuterium Analogs of Pharmaceuticals

  • 期刊论文

  • 发表日期：

    2026年1月1日

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  • V. P. Shevchenko,
  • I. Yu. Nagaev,
  • K. V. Shevchenko,
  • L. A. Andreeva,
  • N. F. Myasoedov

摘要

Isotopically labeled compounds have played and continue to play a significant role in biological research. A new stage in their use is currently emerging, unique in that deuterium compounds are being offered as pharmaceuticals. The chemistry of isotopically labeled compounds is evolving into medicinal chemistry. The synthesis of deuterium-based drugs is becoming a pressing issue. The present review examines various approaches to producing deuterium drugs such as deuterium introduction by heterogeneous isotope exchange using D2 and D2O; synthesis of labeled compounds using labeled reagents, labeled precursors, and homogeneous catalysts; and deuterium introduction using chemical synthesis.