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<p>A simple capillary zone electrophoresis (CZE) version suitable for fast and efficient quantification of <sup>25</sup>Mg<sup>2+</sup>-carrying porphyrin-fullerene cation-exchanger nanoparticles in rat brain tissue carried out during preclinical studies of this type of novel nanoprotectors was proposed. The potential application of this technique for resolving pharmacokinetic tasks is under discussion with the emphasis on a comparison to the routine protocol chromatographic procedures (HPLC, TLC, etc.).</p>

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Capillary Zone Electrophoresis: A Novel Approach to Pharmacokinetic Studies of Porphyrin-C60-Based Neuroprotectors

  • 期刊论文

  • 发表日期：

    2026年1月1日

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  • A. A. Bukhvostov,
  • S. E. Arkhangelsky,
  • O. V. Kamkina,
  • A. V. Semenova,
  • D. A. Kuznetsov

摘要

A simple capillary zone electrophoresis (CZE) version suitable for fast and efficient quantification of 25Mg2+-carrying porphyrin-fullerene cation-exchanger nanoparticles in rat brain tissue carried out during preclinical studies of this type of novel nanoprotectors was proposed. The potential application of this technique for resolving pharmacokinetic tasks is under discussion with the emphasis on a comparison to the routine protocol chromatographic procedures (HPLC, TLC, etc.).