<p>The anti-inflammatory and antiulcer activity of several glycyrrhizic acid (GA) conjugates with amino-acid methyl/ethyl esters at a dose of 50 mg/kg was studied in a carrageenan-induced paw edema model in mice as compared with voltaren and in an indomethacin-induced gastric ulcer model in rats as compared with omeprazole. The GA conjugate with L-alanine ethyl ester (<b>V</b>) exerted a pronounced anti-inflammatory effect comparable to voltaren, reducing paw edema by 1.8 times (<i>p</i> &lt; 0.01) as compared with the control group and by 1.5 times (<i>p</i> &lt; 0.01) as compared with GA. The highest antiulcer activity, comparable to that of omeprazole, was demonstrated by the GA conjugate containing three residues of L-methionine methyl ester <b>III</b> and the GA conjugate with two residues of aminoenanthic acid methyl ester <b>VII</b>, reducing the number of ulcers as compared to the control by 3.9 times (<i>p</i> &lt; 0.001) and 3.7 times (<i>p</i> &lt; 00.001), respectively. These conjugates reduced the number of ulcers by an average of 3.1 times (<i>p</i> &lt; 0.01) as compared to starting GA.</p>