<p>For a very long time, <i>Syzygium cumini</i> (Myrtaceae) seeds have been used to cure diabetes. Determining the phytoconstituents present in <i>S. cumini</i> seeds was the aim of the current study. The medical establishment still struggles to treat type-2 diabetes without causing harmful side effects. Because of this, the market for natural products with antidiabetic properties and fewer side effects is expanding. <i>S. cumini</i> is a traditional herbal remedy that is reported to have a variety of pharmacological effects. Flavonoids, anthocyanins, terpenoids, tannins, and other phenolic compounds make up its chemical makeup. Phenolic compounds found in <i>S. cumini</i> include flavonoids, which may have antidiabetic properties. The main goal of this work was to use in silico screening to look into the potential antidiabetic activity of <i>S. cumini</i> seed extract against diabetes induced by streptozocin. Preliminary findings from <i>S. cumini</i> seeds demonstrated noteworthy antidiabetic characteristics. These compounds may have antidiabetic effects, which supports the seeds’ traditional use as a diabetes therapy. This knowledge can be applied to the design and development of potent, multifunctional candidate drugs with minimal adverse effects for type-2 diabetes treatment.</p>

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Assessing the Impact of Jamun (Syzygium cumini) Ethanolic Seed Extraction on Diabetic Rats

  • Mazen Almehmadi,
  • Mamdouh Allahyani,
  • Mohammad Asif

摘要

For a very long time, Syzygium cumini (Myrtaceae) seeds have been used to cure diabetes. Determining the phytoconstituents present in S. cumini seeds was the aim of the current study. The medical establishment still struggles to treat type-2 diabetes without causing harmful side effects. Because of this, the market for natural products with antidiabetic properties and fewer side effects is expanding. S. cumini is a traditional herbal remedy that is reported to have a variety of pharmacological effects. Flavonoids, anthocyanins, terpenoids, tannins, and other phenolic compounds make up its chemical makeup. Phenolic compounds found in S. cumini include flavonoids, which may have antidiabetic properties. The main goal of this work was to use in silico screening to look into the potential antidiabetic activity of S. cumini seed extract against diabetes induced by streptozocin. Preliminary findings from S. cumini seeds demonstrated noteworthy antidiabetic characteristics. These compounds may have antidiabetic effects, which supports the seeds’ traditional use as a diabetes therapy. This knowledge can be applied to the design and development of potent, multifunctional candidate drugs with minimal adverse effects for type-2 diabetes treatment.