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<p>Recent research has demonstrated that dihydropyridine-3,5-dicarboxamides have notable anti-tubercular activity. In this study, three new dihydropyridines were designed and prepared using Hantzsch reaction. The structures of synthetized ligands were specified by TLC, IR, and NMR. Based on the <i>in vitro</i> test results, all of the new compounds demonstrated efficient potency to inhibit the mycobacterium tuberculosis growth in terms of MIC. Computational studies were performed on all the prepared ligands.</p>

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Design, Synthesis, and Antimicrobial Activity of Novel 1,4-Dihydropyridine-3,5-Dicarboxamides

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • Yasaman Rasouli,
  • Asghar Davood,
  • Soroush Sardari,
  • Yekta Farahani

摘要

Recent research has demonstrated that dihydropyridine-3,5-dicarboxamides have notable anti-tubercular activity. In this study, three new dihydropyridines were designed and prepared using Hantzsch reaction. The structures of synthetized ligands were specified by TLC, IR, and NMR. Based on the in vitro test results, all of the new compounds demonstrated efficient potency to inhibit the mycobacterium tuberculosis growth in terms of MIC. Computational studies were performed on all the prepared ligands.