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<p>Water-soluble copolymers of acrylamide with 2-aminoethyl methacrylate hydrochloride were obtained by radical copolymerization as polymer carriers for modifying ofloxacin. Their composition, molecular, and hydrodynamic characteristics were studied. An optimal sample of the copolymer suitable as a carrier was selected based on the results. A water-soluble polymeric derivative of ofloxacin ketimine was synthesized, exhibited high anti-tuberculosis activity, and was characterized by prolonged release of the fluoroquinolone.</p>

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Water-Soluble Polymeric Derivative of Ofloxacin Ketimine: Synthesis and Antituberculosis Activity

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • M. Yu. Smirnova,
  • E. B. Tarabukina,
  • M. V. Solovskii,
  • Ya. G. Karpacheva

摘要

Water-soluble copolymers of acrylamide with 2-aminoethyl methacrylate hydrochloride were obtained by radical copolymerization as polymer carriers for modifying ofloxacin. Their composition, molecular, and hydrodynamic characteristics were studied. An optimal sample of the copolymer suitable as a carrier was selected based on the results. A water-soluble polymeric derivative of ofloxacin ketimine was synthesized, exhibited high anti-tuberculosis activity, and was characterized by prolonged release of the fluoroquinolone.