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<p>The design of new drugs by chemical modification of hydroxybenzoic acid derivatives is the leading direction of our research work, the purpose of which is to find low-toxic lead compounds for the design of new pharmacologically active molecules on their basis. In this regard, computer modeling and prediction of the pharmacological parameters of hydroxybenzoic acid amides with L-methionine were implemented. The hepatotropic activity profile was preliminarily assessed. The probabilities of detecting hepatoprotective and lipotropic activity were found. The cytotoxicity was predicted <i>in silico</i>. Several <i>N</i>-(hydroxybenzoyl)methionines were selected based on computer monitoring results and synthesized using a previously developed method. The theoretical absence of cytotoxic effects was confirmed by a direct study of the <i>in vitro</i> cytotoxicity using cell culture technologies and the MTT test.</p>

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Synthesis and Cytotoxicity Study of Some Amides of Hydroxy- and Methoxybenzoic Acids with L-Methionine

  • 期刊论文

  • 发表日期：

    2025年9月1日

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  • A. K. Brel,
  • P. V. Sidorenko,
  • D. S. Yakovlev,
  • S. V. Lisina,
  • M. S. Pshenichnikova,
  • M. L. Usacheva

摘要

The design of new drugs by chemical modification of hydroxybenzoic acid derivatives is the leading direction of our research work, the purpose of which is to find low-toxic lead compounds for the design of new pharmacologically active molecules on their basis. In this regard, computer modeling and prediction of the pharmacological parameters of hydroxybenzoic acid amides with L-methionine were implemented. The hepatotropic activity profile was preliminarily assessed. The probabilities of detecting hepatoprotective and lipotropic activity were found. The cytotoxicity was predicted in silico. Several N-(hydroxybenzoyl)methionines were selected based on computer monitoring results and synthesized using a previously developed method. The theoretical absence of cytotoxic effects was confirmed by a direct study of the in vitro cytotoxicity using cell culture technologies and the MTT test.