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<p>4-Aryl-<i>N</i>-(4-acetylphenyl)-2-hydroxy-4-oxobut-2-enamides were obtained by the reaction of methyl esters of acylpyruvic acids with 4-aminoacetophenone in glacial HOAc in the presence of anhydrous NaOAc. The structures of the compounds were determined by PMR, <sup>13</sup>C NMR, and IR spectroscopy. Pronounced analgesic activity was found for the synthesized compounds. All studied compounds were practically non-toxic.</p>

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Synthesis and Analgesic Activity of 4-Aryl-N-(4-Acetylphenyl)-2-Hydroxy-4-Oxobut-2-Enamides

  • 期刊论文

  • 发表日期：

    2025年7月1日

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  • V. I. Gein,
  • I. V. Turchin,
  • E. A. Nepogodina,
  • O. V. Bobrovskaya,
  • S. V. Chaschina

摘要

4-Aryl-N-(4-acetylphenyl)-2-hydroxy-4-oxobut-2-enamides were obtained by the reaction of methyl esters of acylpyruvic acids with 4-aminoacetophenone in glacial HOAc in the presence of anhydrous NaOAc. The structures of the compounds were determined by PMR, 13C NMR, and IR spectroscopy. Pronounced analgesic activity was found for the synthesized compounds. All studied compounds were practically non-toxic.