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<p>In medicinal and drug discovery benzimidazole heterocyclic compounds have a special relevance owing to their chemotherapeutic potential, with less detrimental consequences and an extensive spectrum of biological activity. In this investigation, we reported the synthesis, characterization, and biological evaluation of 2-substituted benzimidazole derivatives as antifungals. The present designed benzimidazole derivatives were synthesized by the condensation method using different acids and aldehydes. <i>O</i>-Phenylenediamine was used as the starting material. Furthermore, the agar well diffusion method and culture tube method were performed to examine the <i>in vitro</i> antifungal activity of newly synthesized derivatives against <i>Candida tropicalis</i>. It was observed that all of the proposed benzimidazole synthesized derivatives showed considerable antifungal activity and could potentially be exploited as potent and effective leads for antifungal drugs in the future.</p>

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Synthesis, Characterization and Biological Evaluation of 2-Substituted Benzimidazole Derivatives as Antifungal Compounds

  • 期刊论文

  • 发表日期：

    2025年5月1日

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  • Monika Chauhan,
  • Nisha Rajpoot,
  • Tulika Anthwal,
  • Swati Pant,
  • Sumitra Nain

摘要

In medicinal and drug discovery benzimidazole heterocyclic compounds have a special relevance owing to their chemotherapeutic potential, with less detrimental consequences and an extensive spectrum of biological activity. In this investigation, we reported the synthesis, characterization, and biological evaluation of 2-substituted benzimidazole derivatives as antifungals. The present designed benzimidazole derivatives were synthesized by the condensation method using different acids and aldehydes. O-Phenylenediamine was used as the starting material. Furthermore, the agar well diffusion method and culture tube method were performed to examine the in vitro antifungal activity of newly synthesized derivatives against Candida tropicalis. It was observed that all of the proposed benzimidazole synthesized derivatives showed considerable antifungal activity and could potentially be exploited as potent and effective leads for antifungal drugs in the future.