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<p>In the presented work, proton transfer salts 1-(pyridin-1-ium-2-yl)piperazin-1-ium 2-hydroxy-5-sulfonato-benzoate, (pypipH<sub>2</sub>)(Hssa), and 1-cyclohexylpiperazine-1,4-diium 2-hydroxy-5-sulfonatobenzoate, (cychpipH<sub>2</sub>)(Hssa), were synthesized from the reaction of 5-sulfosalicylic acid (H<sub>3</sub>ssa) with 1-(pyridin-2-yl)piperazine (pypip) and 1-cyclohexylpiperazine (cychpip) respectively. Cu(II) complexes (pypipH<sub>2</sub>)[Cu(Hssa)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>]×3H<sub>2</sub>O and [Cu(Hssa)(cychpip)(H<sub>2</sub>O)]×H<sub>2</sub>O of the synthesized salts were also synthesized. The structures of compounds were elucidated by Nuclear Magnetic Resonance (<sup>1</sup>H and <sup>13</sup>C-NMR, for salts), Fourier transform infrared, ultraviolet–visible, and atomic absorption (for complexes) spectral methods, and thermal and elemental analyses. Molar conductivity and magnetic measurements were also made for complexes. The biological properties of the salts and their Cu(II) complexes were assayed against Gram-positive <i>Staphylococcus aureus</i> (ATCC 29213), Gram-negative <i>Escherichia coli</i> (ATCC 25922), and yeast microorganisms <i>Candida krusei</i> (ATCC 6258) and <i>Candida parapsilosis</i> (ATCC 22019). The antimicrobial test values of compounds were compared with the commercially available antibacterial (levofloxacin, cefepime, and vancomycin) and the antifungal (vluconazole) control compounds.</p>

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Synthesis, Characterization and Antimicrobial Activity of Two Proton Transfer Salts, 1-(Pyridin-1-ium-2-yl)Piperazin-1-ium2-Hydroxy-5-Sulfonatobenzoate and Cyclohexylpiperazine-1,4-Diium Hydroxy-5-Sulfonatobenzoate, and Their Cu(Ii) Complexes

  • 期刊论文

  • 发表日期：

    2025年5月1日

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  • N. Büyükkıdan,
  • H. İlkimen,
  • B. Durmuş,
  • A. Gülbandılar

摘要

In the presented work, proton transfer salts 1-(pyridin-1-ium-2-yl)piperazin-1-ium 2-hydroxy-5-sulfonato-benzoate, (pypipH2)(Hssa), and 1-cyclohexylpiperazine-1,4-diium 2-hydroxy-5-sulfonatobenzoate, (cychpipH2)(Hssa), were synthesized from the reaction of 5-sulfosalicylic acid (H3ssa) with 1-(pyridin-2-yl)piperazine (pypip) and 1-cyclohexylpiperazine (cychpip) respectively. Cu(II) complexes (pypipH2)[Cu(Hssa)2(H2O)2]×3H2O and [Cu(Hssa)(cychpip)(H2O)]×H2O of the synthesized salts were also synthesized. The structures of compounds were elucidated by Nuclear Magnetic Resonance (1H and 13C-NMR, for salts), Fourier transform infrared, ultraviolet–visible, and atomic absorption (for complexes) spectral methods, and thermal and elemental analyses. Molar conductivity and magnetic measurements were also made for complexes. The biological properties of the salts and their Cu(II) complexes were assayed against Gram-positive Staphylococcus aureus (ATCC 29213), Gram-negative Escherichia coli (ATCC 25922), and yeast microorganisms Candida krusei (ATCC 6258) and Candida parapsilosis (ATCC 22019). The antimicrobial test values of compounds were compared with the commercially available antibacterial (levofloxacin, cefepime, and vancomycin) and the antifungal (vluconazole) control compounds.