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<p>Ketotifen hydrochloride is an antihistamine drug that reduces the effect of histamine in the body and is responsible for allergy symptoms including sneezing, itching, watery eyes, and runny nose. In the present review, we have focused on the methods used to synthesize ketotifen as an active pharmaceutical ingredient (API), its intermediates, and related compounds reported in the literature. This review gives a complete picture of ketotifen synthesis and provides the opportunity for the synthesis of other drugs to increase activity or reduce side effects. This review article is important because it is the first on this topic and gives a complete picture of the synthesis of ketotifen and related compounds and allows synthesis of other drugs to increase activity or reduce side effects.</p>

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Advances in Ketotifen (API) Synthetic Methods, Starting Materials and Related Compounds: a Review

  • 期刊论文

  • 发表日期：

    2025年5月1日

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  • Korany A. Ali,
  • Eman Ali Ragab

摘要

Ketotifen hydrochloride is an antihistamine drug that reduces the effect of histamine in the body and is responsible for allergy symptoms including sneezing, itching, watery eyes, and runny nose. In the present review, we have focused on the methods used to synthesize ketotifen as an active pharmaceutical ingredient (API), its intermediates, and related compounds reported in the literature. This review gives a complete picture of ketotifen synthesis and provides the opportunity for the synthesis of other drugs to increase activity or reduce side effects. This review article is important because it is the first on this topic and gives a complete picture of the synthesis of ketotifen and related compounds and allows synthesis of other drugs to increase activity or reduce side effects.