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<p>The resazurin test was used to show that acetone extracts of <i>Podophyllum peltatum</i> L. organs reduced the viability of rat fibroblasts by 33 – 39%; extracts of callus cultures of this plant, by 35 – 50%; and extracts of 14-d suspension culture at the maximum concentration, by 22%. The cytotoxic activity of the studied extracts for normal cells (rat fibroblasts) was 23% less than for HeLa tumor cells, which validated the potential of these extracts as medicinal plant raw material for producing drugs with antitumor activity.</p>

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Cytotoxic Activity of Acetone Extracts of Podophyllum peltatum L. Plant Organs and Cell Cultures in Relation to Normal and Tumor Cells

  • 期刊论文

  • 发表日期：

    2025年3月1日

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  • M. P. Kitaeva,
  • T. A. Fedotcheva,
  • N. L. Shimanovsky

摘要

The resazurin test was used to show that acetone extracts of Podophyllum peltatum L. organs reduced the viability of rat fibroblasts by 33 – 39%; extracts of callus cultures of this plant, by 35 – 50%; and extracts of 14-d suspension culture at the maximum concentration, by 22%. The cytotoxic activity of the studied extracts for normal cells (rat fibroblasts) was 23% less than for HeLa tumor cells, which validated the potential of these extracts as medicinal plant raw material for producing drugs with antitumor activity.