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<p>The emergence and spread of resistant strains of <i>Klebsiella pneumoniae</i> leads to a decrease in the effectiveness of antibiotics currently used in therapeutic practice. The search for new drugs against this dangerous pathogen is conducted in several directions, including targeted synthesis of new substances with anti-klebsiellosis activity; the search for new targets for the action of potential drugs, including on the basis of metabolic modeling on the scale of the <i>K. pneumoniae</i> genome; screening for antibiotic resistance; identification of potential virulence factors; and a number of other approaches. This review analyzes and summarizes literature data over the past 10 years on the synthesis and study of potential drugs against <i>K. pneumoniae</i> using both an empirical approach and molecular docking.</p>

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Modern Directions in the Search for Drugs in Relation to Klebsiella pneumoniae (A Review)

  • 期刊论文

  • 发表日期：

    2025年3月1日

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  • N. N. Stepkina,
  • A. V. Velikorodov,
  • M. A. Samotrueva,
  • V. Yu. Kotova

摘要

The emergence and spread of resistant strains of Klebsiella pneumoniae leads to a decrease in the effectiveness of antibiotics currently used in therapeutic practice. The search for new drugs against this dangerous pathogen is conducted in several directions, including targeted synthesis of new substances with anti-klebsiellosis activity; the search for new targets for the action of potential drugs, including on the basis of metabolic modeling on the scale of the K. pneumoniae genome; screening for antibiotic resistance; identification of potential virulence factors; and a number of other approaches. This review analyzes and summarizes literature data over the past 10 years on the synthesis and study of potential drugs against K. pneumoniae using both an empirical approach and molecular docking.