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<p>The possibility of using silicon-containing porous particles as a carrier of the therapeutic molecule miR-34a to enhance its antitumor activity was investigated. It was shown by a liquid porometry method that commercially available Fluka 60 silicon nanoparticles could retain the miR-34a molecule in the pore space for a long time and provide a high degree of loading and retention of the microRNA. The proliferative activity of HeLa tumor cell cultures incubated with miR-34a loaded in Fluka 60 was suppressed by 35 – 25%. Free miR-34a had no effect on the proliferation of these cells. It was concluded that Fluka 60 is promising for use as a carrier for microRNA molecules.</p>

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Antiproliferative Activity of Nanoporous Silica-Containing Particles as Carriers of MIR-34A Against Cancer Cell Cultures

  • 期刊论文

  • 发表日期：

    2025年2月1日

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  • A. G. Akopdzhanov,
  • T. I. Pavlik,
  • S. A. Bortnikova,
  • A. A. Belogorlov,
  • N. L. Shimanovsky

摘要

The possibility of using silicon-containing porous particles as a carrier of the therapeutic molecule miR-34a to enhance its antitumor activity was investigated. It was shown by a liquid porometry method that commercially available Fluka 60 silicon nanoparticles could retain the miR-34a molecule in the pore space for a long time and provide a high degree of loading and retention of the microRNA. The proliferative activity of HeLa tumor cell cultures incubated with miR-34a loaded in Fluka 60 was suppressed by 35 – 25%. Free miR-34a had no effect on the proliferation of these cells. It was concluded that Fluka 60 is promising for use as a carrier for microRNA molecules.