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<p>The dried leaves of <i>Chimonanthus salicifolius</i>, which is widely used in Zhejiang, Jiangxi, Anhui and other provinces in China, have high medicinal value and health function. In this study, different extraction methods were employed to extract the volatile oil from <i>Chimonanthus salicifolius</i>. The chemical composition of the volatile oil was analyzed using gas chromatography-mass spectrometry (GC-MS). Based on network pharmacology, the antibacterial action mechanism of the volatile oil from <i>Chimonanthus salicifolius</i> was clarified, and its activity was further evaluated through antimicrobial experiments <i>in vitro</i>. The results show that the extraction efficiency of vacuum extraction was higher than that of atmospheric extraction, and the time from heating to boiling was reduced by one third. Analysis of the volatile oil from <i>Chimonanthus salicifolius</i> identified 50 chemical components, including eucalyptol, paeonol, and α-pinene. The predominant component was eucalyptol, which had the highest content of the volatile oil extracted under vacuum, reaching 87.04%. <i>Chimonanthus salicifolius</i> volatile oil was found to interact with 247 target points and affect 84 signaling pathways related to antibacterial activity. It was observed that the volatile oil extracted under vacuum demonstrated better antibacterial efficacy.</p>

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Evaluation of Antibacterial Mechanism of Volatile Oil from Chimonanthus salicifolius Based on GC-MS Combined with Network Pharmacology

  • 期刊论文

  • 发表日期：

    2025年1月1日

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  • Cong Zhang,
  • Jun-mei Li,
  • Xiao-yi Liu,
  • Ji-zhong Yan,
  • Hui Zhang

摘要

The dried leaves of Chimonanthus salicifolius, which is widely used in Zhejiang, Jiangxi, Anhui and other provinces in China, have high medicinal value and health function. In this study, different extraction methods were employed to extract the volatile oil from Chimonanthus salicifolius. The chemical composition of the volatile oil was analyzed using gas chromatography-mass spectrometry (GC-MS). Based on network pharmacology, the antibacterial action mechanism of the volatile oil from Chimonanthus salicifolius was clarified, and its activity was further evaluated through antimicrobial experiments in vitro. The results show that the extraction efficiency of vacuum extraction was higher than that of atmospheric extraction, and the time from heating to boiling was reduced by one third. Analysis of the volatile oil from Chimonanthus salicifolius identified 50 chemical components, including eucalyptol, paeonol, and α-pinene. The predominant component was eucalyptol, which had the highest content of the volatile oil extracted under vacuum, reaching 87.04%. Chimonanthus salicifolius volatile oil was found to interact with 247 target points and affect 84 signaling pathways related to antibacterial activity. It was observed that the volatile oil extracted under vacuum demonstrated better antibacterial efficacy.